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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(03): 396-401
DOI: 10.4103/ijmpo.ijmpo_10_18
Original Article

Utility of Neutrophil–Lymphocyte Ratio, Platelet–Lymphocyte Ratio, Mean Platelet Volume–Platelet Count Ratios: Diagnostic and Prognostic Markers in Patients with Hepatocellular Carcinoma, Prostate Carcinoma, Stomach Carcinoma, and Aplastic Anemia

V S Srikanth
Department of General Medicine, Amrita Institute of Medical Sciences and Research Centre AIMS, Affiliated to Amrita Vishwa Vidyapeetham, Ponekkara, Kochi, Kerala, India
,
M Gopala Krishna Pillai
Department of General Medicine, Amrita Institute of Medical Sciences and Research Centre AIMS, Affiliated to Amrita Vishwa Vidyapeetham, Ponekkara, Kochi, Kerala, India
,
Cinzia Keechilot
Department of General Medicine, Amrita Institute of Medical Sciences and Research Centre AIMS, Affiliated to Amrita Vishwa Vidyapeetham, Ponekkara, Kochi, Kerala, India
,
Ashwin Rajkumar
Department of General Medicine, Amrita Institute of Medical Sciences and Research Centre AIMS, Affiliated to Amrita Vishwa Vidyapeetham, Ponekkara, Kochi, Kerala, India
,
Tushar Tatineni
Department of Radiation Oncology, Amrita Institute of Medical Sciences and Research Centre AIMS, Affiliated to Amrita Vishwa Vidyapeetham, Ponekkara, Kochi, Kerala, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Introduction: The purpose of the study is to study the potential role of neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and mean platelet volume (MPV)–platelet ratio as diagnostic and prognostic markers in patients with hepatocellular carcinoma (HCC), prostate cancer, stomach cancer, and aplastic anemia. Materials and Methods: We have conducted the present study by screening 208,486 patients who have got admitted during January 2013–June 2017 as in patients in our hospital. The data collected were analyzed for NLR, PLR, and MPV–platelet ratio. Inclusion Criteria: Patients admitted with a diagnosis of HCC, prostate cancer, stomach cancer, and aplastic anemia irrespective of the age and gender. Exclusion Criteria: Patients with multiple malignancies, the presence of secondary infection, and any source of sepsis. SPSS tool was used for statistical analysis. Results: Cost-effective predictive and prognostic biomarkers identified in the study are – NLR for liver cancer, prostate cancer, and stomach cancer; PLR for prostate and stomach cancer; MPV/plate ratio can be used in addition to NLR for liver cancer. These ratios were not significant in aplastic anemia. Conclusion: From our study, we conclude that NLR and PLR are better cost-effective predictor and prognostic markers of HCC, prostate cancer, and stomach cancer. These ratios can be used at the primary health-care level as it can be derived from a simple complete blood count/peripheral smear. Early identification of carcinoma is possible using these potential markers along with the respective clinical presentations and symptoms. These ratios will reduce the financial burden on the patients from rural and low socioeconomic background and will aid in better management of the disease process.

Keywords

Carcinoma - neutrophil–lymphocyte ratio - platelet–lymphocyte ratio - and mean platelet volume/platelet ratio


Publication History

Received: 13 January 2018

Accepted: 27 April 2018

Article published online:
03 June 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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