CC BY-NC-ND 4.0 · Eur J Dent 2018; 12(02): 305-310
DOI: 10.4103/ejd.ejd_402_17
Case Report
European Journal of Dentistry

Central giant cells lesion: Report of a conservative management

Marina Rolo Pinheiro da Rosa
1   Resident of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Amazon State University, Manaus, Brazil
,
Juliana Lopes de Sá
2   Dentistry Student, Department of Oral and Maxillofacial Surgery, Amazon State University, Manaus, Brazil
,
Valber Barbosa Martins
3   Professor at the Residence in Maxillofacial and Traumatology Surgery, Department of Oral and Maxillofacial Surgery, Amazon State University, Manaus, Brazil
,
Marcelo Vinícius de Oliveira
3   Professor at the Residence in Maxillofacial and Traumatology Surgery, Department of Oral and Maxillofacial Surgery, Amazon State University, Manaus, Brazil
› Author Affiliations
Further Information

Publication History

Publication Date:
16 September 2019 (online)

ABSTRACT

Central giant cells lesion (CGCL) is defined as a benign intraosseous destructive pathology. It is classified as aggressive or nonaggressive, depending on their clinical, imaginologic, and histological behavior. The behavior, location, and extension of the lesion added to the patient's age will determine the choice of the treatment, either surgical or clinical. Thereby, the aim of this work is to review the literature related to the CGCL, as well as to present a clinical case report of a 22-year-old female patient, affected with an injury on the left side of her jaw. After the diagnosis, it was decided to carry out a conservative treatment with intralesional injections of triamcinolone (10 mg/ml). The injections were performed once a week for 6 weeks. The progress of the patient was satisfactory, and after 4 years, it has been observed through imaging and clinical bone formation examinations with complete remission of the injury and no signs of recurrence.

 
  • REFERENCES

  • 1 Kramer IR, Pindborg JJ, Shear M. Histological Typing of Odontogenic Tumors. 2nd. ed Berlin: Springer-Verlag; 1991: p. 31
  • 2 Austin Jr LT, Dahlin DC, Royer RQ. Giant-cell reparative granuloma and related conditions affecting the jawbones. Oral Surg Oral Med Oral Pathol 1959; 12: 1285-95
  • 3 Kaffe I, Ardekian L, Taicher S, Littner MM, Buchner A. Radiologic features of central giant cell granuloma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 81: 720-6
  • 4 Kurtz M, Mesa M, Alberto P. Treatment of a central giant cell lesion of the mandible with intralesional glucocorticosteroids. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 91: 636-7
  • 5 Yamaguchi T, Dorfman HD, Eisig S. Cherubism: Clinicopathologic features. Skeletal Radiol 1999; 28: 350-3
  • 6 Boedeker CC, Kayser G, Ridder GJ, Maier W, Schipper J. Giant-cell reparative granuloma of the temporal bone: A case report and review of the literature. Ear Nose Throat J 2003; 82: 926-929 , 933-934 , 936-937
  • 7 Kauzman A, Li SQ, Bradley G, Bell RS, Wunder JS, Kandel R. et al. Central giant cell granuloma of the jaws: Assessment of cell cycle proteins. J Oral Pathol Med 2004; 33: 170-6
  • 8 Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd. ed Rio de Janeiro: Elsevier; 2009;
  • 9 Waldron CA, Shafer WG. The central giant cell reparative granuloma of the jaws. An analysis of 38 cases. Am J Clin Pathol 1966; 45: 437-47
  • 10 Chuong R, Kaban LB, Kozakewich H, Perez-Atayde A. Central giant cell lesions of the jaws: A clinicopathologic study. J Oral Maxillofac Surg 1986; 44: 708-13
  • 11 Cohen MA, Hertzanu Y. Radiologic features, including those seen with computed tomography, of central giant cell granuloma of the jaws. Oral Surg Oral Med Oral Pathol 1988; 65: 255-61
  • 12 Whitaker SB, Waldron CA. Central giant cell lesions of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1993; 75: 199-208
  • 13 Sidhu MS, Parkash H, Sidhu SS. Central giant cell granuloma of jaws – Review of 19 cases. Br J Oral Maxillofac Surg 1995; 33: 43-6
  • 14 Kruse-Lösler B, Diallo R, Gaertner C, Mischke KL, Joos U, Kleinheinz J. et al. Central giant cell granuloma of the jaws: A clinical, radiologic, and histopathologic study of 26 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101: 346-54
  • 15 Bodner L, Bar-Ziv J. Radiographic features of central giant cell granuloma of the jaws in children. Pediatr Radiol 1996; 26: 148-51
  • 16 Katz A, Hirschl S. Giant cell reparative granuloma in the temporal bone. Arch Otolaryngol 1974; 100: 380-2
  • 17 Üstündağ E, Iseri M, Keskin G, Müezzinoğlu B. Central giant cell granuloma. Int J Pediatr Otorhinolaryngol 2002; 65: 143-6
  • 18 Webb DJ, Brockbank J. Combined curettage and cryosurgical treatment for the aggressive “giant cell lesion” of the mandible. Int J Oral Maxillofac 1986; 15: 780-85
  • 19 Bataineh AB, Al-Khateeb T, Rawashdeh MA. The surgical treatment of central giant cell granuloma of the mandible. J Oral Maxillofac Surg 2002; 60: 756-61
  • 20 Harris M. Central giant cell granulomas of the jaws regress with calcitonin therapy. Br J Oral Maxillofac Surg 1993; 31: 89-94
  • 21 de Lange J, Rosenberg AJ, van den Akker HP, Koole R, Wirds JJ, van den Berg H. et al. Treatment of central giant cell granuloma of the jaw with calcitonin. Int J Oral Maxillofac Surg 1999; 28: 372-6
  • 22 Pogrel MA. Calcitonin therapy for central giant cell granuloma. J Oral Maxillofac Surg 2003; 61: 649-53
  • 23 Terry BC, Jacoway JR. Management of central giant cell lesion: An alternative to surgical therapy. Oral Maxillofac Surg Clin North Am 1994; 6: 579-600
  • 24 Carlos R, Sedano HO. Intralesional corticosteroids as an alternative treatment for central giant cell granuloma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 93: 161-6
  • 25 Abdo EN, Alves LC, Rodrigues AS, Mesquita RA, Gomez RS. Treatment of a central giant cell granuloma with intralesional corticosteroid. Br J Oral Maxillofac Surg 2005; 43: 74-6
  • 26 Kermer C, Millesi W, Watzke IM. Local injection of corticosteroids for central giant cell granuloma. A case report. Int J Oral Maxillofac Surg 1994; 23: 366-8
  • 27 Nogueira RL, Teixeira RC, Cavalcante RB, Ribeiro RA, Rabenhosrt SH. Intralesional injection of triamcinolone hexacetonide as an alternative treatment for central giant-cell granuloma in 21 cases. Int J Oral Maxillofac Surg 2010; 39: 1204-10
  • 28 Rajeevan NS, Soumithran CS. Intralesional corticosteroid injection for central giant cell granuloma. A case report. Int J Oral Maxillofac Surg 1998; 27: 303-4
  • 29 Adornato MC, Paticoff KA. Intralesional corticosteroid injection for treatment of central giant-cell granuloma. J Am Dent Assoc 2001; 132: 186-90
  • 30 Ferretti C, Muthray E. Management of central giant cell granuloma of mandible using intralesional corticosteroids: Case report and review of literature. J Oral Maxillofac Surg 2011; 69: 2824-9
  • 31 Vered M, Buchner A, Dayan D. Immunohistochemical expression of glucocorticoid and calcitonin receptors as a tool for selecting therapeutic approach in central giant cell granuloma of the jawbones. Int J Oral Maxillofac Surg 2006; 35: 756-60
  • 32 Lange J, Akker HP. Clinical and radiological features of central giant-cell lesions of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 99: 464-70
  • 33 Eckardt A, Pogrel MA, Kaban LB, Chew K, Mayall BH. Central giant cells granuloma of the jaws. Int J Oral Maxillofac Surg 1989; 18: 3-6
  • 34 Eisenbud L, Stern M, Rothberg M, Sachs SA. Central giant cell granuloma of the jaws: Experiences in the management of thirty-seven cases. J Oral Maxillofac Surg 1988; 46: 376-84
  • 35 O'Regan EM, Gibb DH, Odell EW. Rapid growth of giant cell granuloma in pregnancy treated with calcitonin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 92: 532-8
  • 36 Lange J, Akker HP, Berg H, Richel DJ, Gortzak RA. Limited regression of central giant cell granuloma by interferon alpha failed calcitonin therapy: A report of 2 cases. Int J Oral Maxillofac Surg 2006; 35: 865-9