Efficacy of transcutaneous electrical nerve stimulation on salivary flow rates in normal healthy adults according to gender and age groups

C Ramesh; Sharad Sawant; Deepak Kolte; Barun Kumar; Kosuru Kranthi; Tejal Patil; J Babu; C Swarnalatha; Abhishek Nayyar

doi:10.4103/ajns.AJNS_48_21

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CC BY-NC-ND 4.0 · Asian J Neurosurg 2021; 16(04): 770-776
DOI: 10.4103/ajns.AJNS_48_21

Original Article

Efficacy of transcutaneous electrical nerve stimulation on salivary flow rates in normal healthy adults according to gender and age groups

C Ramesh

Department of Dentistry, Shri Sathya Sai Medical College and Research Institute, Ammapettai, Nellikuppam Post, Chengalpattu District, Nellikuppam, Tamil Nadu

,

Sharad Sawant

¹Department of General Surgery, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli

,

Deepak Kolte

²Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai

,

Barun Kumar

²Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai

,

Kosuru Kranthi

³Department of Periodontology, Meghna Institute of Dental Sciences, Nizamabad, Telangana

,

Tejal Patil

²Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai

,

J Babu

⁴Division of Periodontology, Department of Preventive Dental Sciences, College of Dentistry, University of Ha'il, Ha'il

,

C Swarnalatha

⁴Division of Periodontology, Department of Preventive Dental Sciences, College of Dentistry, University of Ha'il, Ha'il

,

Abhishek Nayyar

⁵Department of Oral Medicine and Radiology, Saraswati Dhanwantari Dental College and Hospital and Post-Graduate Research Institute, Parbhani, Maharashtra

› Author Affiliations

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Abstract
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Introduction: Salivary gland hypofunction might be associated with various local and systemic conditions and is managed with a plethora of therapeutic options with associated side effects. Transcutaneous electrical nerve stimulation (TENS) is one such option with no known systemic side effects for dealing with this crippling condition. The present study was planned with a similar intent of assessing impact of TENS on salivary flow rates in normal healthy adults according to gender and age groups. Materials and Methods: The present study was designed as a cross-sectional study on 130 healthy adults wherein unstimulated and stimulated saliva was collected for 5 min in graduated test tubes fitted with a funnel while mean salivary flow rates were calculated. The data were analyzed using SPSS version 17.0 (SPSS Inc., Chicago, IL, USA). Results: In the present study, differences between mean unstimulated and stimulated salivary flow rates with TENS were found to be statistically significant for both genders (P < 0.001). Furthermore, in relation to age groups included, maximum increase in salivary flow rate was seen in 20–29 years of age group, though significant results were seen in all three age groups included namely 20–29 years, 30–39 years, and 40–49 years (P < 0.001). Conclusions: Based on results from the present study, it could be concluded that TENS comes out to be a safer, nonpharmacological therapeutic option for treating patients with xerostomia.

Key-words:

Saliva - salivary glands - transcutaneous electric nerve stimulation - xerostomia

Financial support and sponsorship

Nil.

Publication History

Received: 31 January 2021

Accepted: 03 August 2021

Article published online:
16 August 2022

© 2021. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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References
1 Singh D, Agrawal S, Shashikanth MC, Misra N. The effects of transcutaneous electrical nerve stimulation (TENS) on salivary flow: A study. J Indian Acad Oral Med Radiol 2015;27:16-9.
2 Aggarwal H, Pal-Singh M, Mathur H, Astekar S, Gulati P, Lakhani S. Evaluation of the effect of transcutaneous electrical nerve stimulation (TENS) on whole salivary flow rate. J Clin Exp Dent 2015;7:e13-7.
3 Vilas SK, Shashikanth MC, Ali IM. Evaluation of the effect of transcutaneous electrical nerve stimulation on whole saliva flow: A clinical study. J Indian Acad Oral Med Radiol 2009;21:7-11.
4 Sarapur S, Shilpashree HS. Salivary pacemakers: A review. Dent Res J (Isfahan) 2012;9:S20-5.
5 Lafaurie G, Fedele S, López RM, Wolff A, Strietzel F, Porter SR, et al. Biotechnological advances in neuro-electro-stimulation for the treatment of hyposalivation and xerostomia. Med Oral Patol Oral Cir Bucal 2009;14:E76-80.
6 Mittal K, Keluskar V, Kapoor S. Evaluation of the effect of transcutaneous electrical nerve stimulation (TENS) on salivary flow in patients with Xerostomia. Annals of Dent Res 2012;2:44-50.
7 Strietzel FP, Martín-Granizo R, Fedele S, Lo Russo L, Mignogna M, Reichart PA, et al. Electrostimulating device in the management of xerostomia. Oral Dis 2007;13:206-13.
8 Greenspan D. Xerostomia: Diagnosis and management. Oncol (Williston Park) 1996;10:7-11.
9 Vance CG, Dailey DL, Rakel BA, Sluka KA. Using TENS for pain control: The state of the evidence. Pain Manag 2014;4:197-209.
10 Johnson M. Transcutaneous electrical nerve stimulation: Mechanisms, clinical application and evidence. Rev Pain 2007;1:7-11.
11 Walsh D. TENS: Clinical Applications and Related Theory. 1st ed. New York: Churchill Livingstone; 1997.
12 Johnson M. Transcutaneous Electrical Nerve Stimulation, in Electrotherapy: Evidence Based Practice. In: Watson T., Editor. Edinburgh: Churchill Livingstone; 2008. p. 253-96.
13 Garrison DW, Foreman RD. Decreased activity of spontaneous and noxiously evoked dorsal horn cells during transcutaneous electrical nerve stimulation (TENS). Pain 1994;58:309-15.
14 Sluka KA, Walsh D. Transcutaneous electrical nerve stimulation: Basic science mechanisms and clinical effectiveness. J Pain 2003;4:109-21.
15 Palmer ST, Martin DJ, Steedman WM, Ravey J. Effects of electric stimulation on C and A delta fiber-mediated thermal perception thresholds. Arch Phys Med Rehabil 2004;85:119-28.
16 Chesterton LS, Foster NE, Wright CC, Baxter GD, Barlas P. Effects of TENS frequency, intensity and stimulation site parameter manipulation on pressure pain thresholds in healthy human subjects. Pain 2003;106:73-80.
17 Claydon LS, Chesterton LS, Barlas P, Sim J. Alternating-frequency TENS effects on experimental pain in healthy human participants: A randomized placebo-controlled trial. Clin J Pain 2013;29:533-9.
18 Chesterton LS, Barlas P, Foster NE, Lundeberg T, Wright CC, Baxter GD. Sensory stimulation (TENS): Effects of parameter manipulation on mechanical pain thresholds in healthy human subjects. Pain 2002;99:253-62.
19 Barlas P, Lundeberg T. Transcutaneous Electrical Nerve Stimulation and Acupuncture. In: Melzack and Wall's Textbook of Pain. McMahon S, Koltzenburg M, Editors. Philadelphia: Elsevier Churchill Livingstone; 2006. p. 583-90.
20 Melzack R, Wall PD. Pain mechanisms: A new theory. Science 1965;150:971-9.
21 Walsh DM, Baxter D. Transcutaneous electrical nerve stimulation (TENS): A review of experimental studies. Eur J Phys Med Rehabil 1996;6:42-50.
22 Shanahan C, Ward AR, Robertson VJ. Comparison of the analgesic efficacy of interferential therapy and transcutaneous electrical nerve stimulation. Physiotherapy 2006;92:247-53.
23 Alves-Guerreiro J, Noble JG, Lowe AS, Walsh DM. The effect of three electrotherapeutic modalities upon peripheral nerve conduction and mechanical pain threshold. Clin Physiol 2001;21:704-11.
24 Johnson M. Transcutaneous electrical nerve stimulation (TENS) and TENS-like devices: Do they provide pain relief? Pain Rev 2001;8:121-8.
25 Johnson MI. A critical review of the analgesic effects of TENS-like devices. Phys Ther Rev 2001;6:153-73.
26 Johnson MI. The clinical effectiveness of TENS in pain management. Phys Rehabil Med 2000;12:131-49.
27 Ainsworth L, Budelier K, Clinesmith M, Fiedler A, Landstrom R, Leeper BJ, et al. Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation. Pain 2006;120:182-7.
28 Brosseau L, Milne S, Robinson V, Marchand S, Shea B, Wells G, et al. Efficacy of the transcutaneous electrical nerve stimulation for the treatment of chronic low back pain: A meta-analysis. Spine (Phila Pa 1976) 2002;27:596-603.
29 Chen C, Tabasam G, Johnson M. Does the pulse frequency of transcutaneous electrical nerve stimulation (TENS) influence hypoalgesia? A systematic review of studies using experimental pain and healthy human participants. Physiotherapy 2008;94:11-20.
30 Jarzem PF, Harvey EJ, Arcaro N, Kaczorowski J. Transcutaneous electrical nerve stimulation (TENS) for chronic low-back pain. J Musculoskelet Pain 2005;13:3-9.
31 Johnson M, Martinson M. Efficacy of electrical nerve stimulation for chronic musculoskeletal pain: A meta-analysis of randomized controlled trials. Pain 2007;130:157-65.
32 Cosmo P, Svensson H, Bornmyr S, Wikström SO. Effects of transcutaneous nerve stimulation on the microcirculation in chronic leg ulcers. Scand J Plast Reconstr Surg Hand Surg 2000;34:61-4.
33 Khadilkar A, Milne S, Brosseau L, Wells G, Tugwell P, Robinson V, et al. Transcutaneous electrical nerve stimulation for the treatment of chronic low back pain: A systematic review. Spine (Phila Pa 1976) 2005;30:2657-66.
34 Domingo DL. The effects of electro-stimulation on saliva production in post-radiation head and neck cancer patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;97:464.
35 Robb K, Oxberry SG, Bennett MI, Johnson MI, Simpson KH, Searle RD. A cochrane systematic review of transcutaneous electrical nerve stimulation for cancer pain. J Pain Symptom Manage 2009;37:746-53.
36 Robb KA, Newham DJ, Williams JE. Transcutaneous electrical nerve stimulation vs. transcutaneous spinal electroanalgesia for chronic pain associated with breast cancer treatments. J Pain Symptom Manage 2007;33:410-9.
37 Searle RD, Bennett MI, Johnson MI, Callin S, Radford H. Transcutaneous electrical nerve stimulation (TENS) for cancer bone pain. J Pain Symptom Manage 2009;37:424-8.
38 Pattipati S, Patil R, Kannan N, Kumar BP, Shirisharani G, Mohammed RB. Effect of transcutaneous electrical nerve stimulation induced parotid stimulation on salivary flow. Contemp Clin Dent 2013;4:427-31.
39 Steller M, Chou L, Daniels TE. Electrical stimulation of salivary flow in patients with Sjögren's syndrome. J Dent Res 1988;67:1334-7.
40 Dyasnoor S, Kamath S, Khader NF. Effectiveness of electrostimulation on whole salivary flow among patients with type 2 diabetes mellitus. Perm J 2017;21:15-164.
41 Vijayalaxmi BN, Ramesh T, Sudhakara RR, Lavanya RR, Swapna LA. Effect of TENS on whole saliva in healthy adult Indians: Evaluation of influence of protocol on quantity of saliva measured. Cumhuriyet Dent J 2012;15:235-40.
42 Bhasin N, Reddy S, Nagarajappa AK, Kakkad A. A study on duration of effect of transcutaneous electrical nerve stimulation therapy on whole saliva flow. J Contemp Dent Pract 2015;16:479-85.
43 Dhillon M, Raju SM, Mohan RS, Tomar D. Efficacy of transcutaneous electrical nerve stimulation on parotid saliva flow rate in relation to age and gender. J Dent Shiraz Univ Med Sci 2016;17:164-70.
44 Konidena A, Sharma D, Puri G, Dixit A, Jatti D, Gupta R. Effect of TENS on stimulation of saliva in postmenopausal women with or without oral dryness – An interventional study. J Oral Biol Craniofac Res 2016;6:S44-50.
45 Talal N, Quinn JH, Daniels TE. The clinical effects of electro-stimulation on salivary function of Sjogren's syndrome patients. Rheumatol Int 1992;12:43-5.
46 Wong RK, Jones GW, Sagar SM, Babjak AF, Whelan T. A Phase I-II study in the use of acupuncture-like transcutaneous nerve stimulation in the treatment of radiation-induced xerostomia in head-and-neck cancer patients treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 2003;57:472-80.
47 Wong RK, James JL, Sagar S, Wyatt G, Nguyen-Tân PF, Singh AK, et al. Phase 2 results from radiation therapy oncology group study 0537: A phase 2/3 study comparing acupuncture-like transcutaneous electrical nerve stimulation versus pilocarpine in treating early radiation-induced xerostomia. Cancer 2012;118:4244-52.
48 Aparna PV, Sankari SL, Deivanayagi M, Priyadharshini A, Vishnupriya CK, Niveditha B. Effect of transcutaneous electrical nerve stimulation on parotid saliva flow in patients with hyposalivation. J Pharm Bioallied Sci 2017;9:S142-6.
49 Percival RS, Challacombe SJ, Marsh PD. Flow rates of resting whole and stimulated parotid saliva in relation to age and gender. J Dent Res 1994;73:1416-20.

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Efficacy of transcutaneous electrical nerve stimulation on salivary flow rates in normal healthy adults according to gender and age groups

Key-words:

Financial support and sponsorship

Publication History

References