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CC BY-NC-ND 4.0 · Asian J Neurosurg 2018; 13(03): 664-668
DOI: 10.4103/ajns.AJNS_294_16
Original Article

Effect of local N-acetyl-cysteine in the prevention of epidural fibrosis in rat laminectomy model

Reza Bahrami
Department of Neurosurgery, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
,
Ehsan Akbari
Department of Neurosurgery, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
,
Salih Rasras
Department of Neurosurgery, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
,
Nematollah Jazayeri
1   Department of Pathology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
,
Mohammad Khodayar
2   Department of Pharmacology and Toxicology, School of Pharmacy, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
,
Hossein Foruozandeh
3   Gerash Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash
,
Masoud Zeinali
Department of Neurosurgery, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
,
Mozhdeh Kartalaei
4   Department of Cardiology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
,
Mohammad Ardeshiri
Department of Neurosurgery, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
,
Farshid Baiatinia
Department of Neurosurgery, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
,
Mohamad Ghanavatian
Department of Neurosurgery, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
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Background: Epidural fibrosis is a major contributing factor to the onset of failed back syndrome. Many studies have attempted to prevent this physiological response. Interestingly, N-acetyl-cysteine (NAC) has been effective in some cases in the treatment of pulmonary fibrosis. Objective: The objective of this study was to determine whether local NAC is an effective way to prevent epidural fibrosis after laminectomy in rats. Materials and Methods: Twenty Wistar rats were used in this study. Animals were divided into two groups: NAC group and a control group. We performed two-level laminectomy (L4–L5) in these rats. Rats in the control group just had laminectomy, and in the other group, L4 and L5 laminectomy followed by local treatment with NAC. Four weeks later, the rats were killed, and the laminectomy level was subjected to histopathological examination to evaluate epidural fibrosis and fibroblast density. Results: Histopathological examination showed that after 4 weeks of surgery the NAC group had significantly less epidural fibrosis and fibroblasts compared with control group. Conclusion: Our findings indicate that NAC decreased spinal epidural fibrosis after laminectomy in rats.

Key-words:

Epidural fibrosis - failed back syndrome - fibroblast - laminectomy - N-acetyl cysteine - rat


Publication History

Article published online:
14 September 2022

© 2018. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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