Subscribe to RSS
![](/products/assets/desktop/img/oa-logo.png)
DOI: 10.4103/ajns.AJNS_256_18
Meningiomas with collagenous rosettes: A report of three cases
![](https://www.thieme-connect.de/media/10.1055-s-00053244/201902/lookinside/thumbnails/10-4103-ajns-ajns-256-18_257190-1.jpg)
Formation of rosettes is very rarely encountered in meningiomas. The 2016 WHO classification of central nervous system tumors mentions it as a rare pattern secondarily encountered in different variants. We report three cases of meningiomas forming collagenous rosettes. Case 1 was a 60-year-old male with a right frontoparietal mass lesion. Excisional biopsy showed features of atypical meningioma (WHO Grade II) with diffusely scattered collagenous rosettes. Case 2 was a 48-year-old male with right frontoparietal space-occupying lesion. Microscopy revealed a papillary variant of meningioma (WHO Grade III) with prominent diffusely scattered collagenous rosettes. Case 3 was a 75-year-old female with left parietal convexity tumor. Microscopy revealed a clear-cell meningioma (WHO Grade II) with cerebral invasion. Focal collagenous rosettes and fibrosclerotic whorls were noted. In all three cases, Masson's trichrome was used to confirm collagenous nature of the rosettes. All three tumors were positive for epithelial membrane antigen and vimentin.
Key-words:
Atypical meningioma - clear-cell meningioma - collagenous rosettes - papillary meningiomaFinancial support and sponsorship
Nil.
Publication History
Article published online:
09 September 2022
© 2019. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. WHO Classification of Tumours of the Central Nervous System. 4th ed. IARC: Lyon; 2016.
- 2 Liverman C, Mafra M, Chuang SS, Shivane A, Chakrabarty A, Highley R, et al. Aclinicopathologic study of 11 rosette-forming meningiomas: A rare and potentially confusing pattern. Acta Neuropathol 2015;130:311-3.
- 3 Tada T, Ishii K, Oshima S, Hara H, Kobayashi S. Secretory meningioma associated with numerous meningothelial rosettes. Acta Neuropathol 1992;84:342-5.
- 4 Kepes JJ. Presidential address: The histopathology of meningiomas. A reflection of origins and expected behavior? J Neuropathol Exp Neurol 1986;45:95-107.
- 5 Haybaeck J, Smolle E, Schökler B, Kleinert R. The WHO grade I collagen-forming meningioma produces angiogenic substances. A New meningioma entity. Anticancer Res 2016;36:941-9.
- 6 Yamashima T. Meningothelial rosettes in the canine subarachnoid space. Acta Neuropathol 1985;66:223-32.