Download PDF
CC BY-NC-ND 4.0 · Asian J Neurosurg 2019; 14(01): 253-255
DOI: 10.4103/ajns.AJNS_176_17
Case Report

Phosphaturic mesenchymal tumors involving skull bones: Report of two rare cases

Toshi Mishra
Department of Histopathology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra
,
Maria Desouza
Department of Histopathology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra
,
Keyuri Patel
Department of Histopathology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra
,
Girish Mazumdar
Department of Histopathology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Phosphaturic mesenchymal tumor (PMT) is a rare tumor causing oncogenic osteomalacia (OO). Most such tumors occur in soft tissue and bones of extremities and appendicular skeleton. Intracranial location and involvement of temporal–occipital bone is extremely rare. We report two unusual cases: The first was intracranial, involving the temporal bone, while the other was a skull base tumor arising from the occipital–temporal bone. Both of them presented with paraneoplastic syndrome of OO, resembled a meningioma radiologically, and underwent gross total resection of tumor. Histologically, both of them were diagnosed as PMT, mixed connective tissue variant.

Key-words:

Fibroblast growth factor-23 - intracranial - oncogenic osteomalacia - phosphaturic mesenchymal tumor - temporal–occipital bone

Financial support and sponsorship

Nil.




Publication History

Article published online:
09 September 2022

© 2019. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Folpe AL, Fanburg-Smith JC, Billings SD, Bisceglia M, Bertoni F, Cho JY, et al. Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: An analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol 2004;28:1-30.
  • 2 Mathis DA, Stehel EJ Jr., Beshay JE, Mickey BE, Folpe AL, Raisanen J, et al. Intracranial phosphaturic mesenchymal tumors: Report of 2 cases. J Neurosurg 2013;118:903-7.
  • 3 David K, Revesz T, Kratimenos G, Krausz T, Crockard HA. Oncogenic osteomalacia associated with a meningeal phosphaturic mesenchymal tumor. Case report. J Neurosurg 1996;84:288-92.
  • 4 Bower RS, Daugherty WP, Giannini C, Parney IF. Intracranial phosphaturic mesenchymal tumor, mixed connective tissue variant presenting without oncogenic osteomalacia. Surg Neurol Int 2012;3:151.
  • 5 Ellis MB, Gridley D, Lal S, Nair GR, Feiz-Erfan I. Phosphaturic mesenchymal tumor of the brain without tumor-induced osteomalacia in an 8-year-old girl: Case report. J Neurosurg Pediatr 2016;17:573-7.
  • 6 Kobayashi K, Nakao K, Kawai K, Ito K, Hukumoto S, Asakage T, et al. Tumor-induced osteomalacia originating from the temporal bone: A case report. Head Neck 2011;33:1072-5.
  • 7 Drezner MK. Tumor-induced osteomalacia. Rev Endocr Metab Disord 2001;2:175-86.
  • 8 Jan de Beur SM. Tumor-induced osteomalacia. JAMA 2005;294:1260-7.
  • 9 Weidner N, Santa Cruz D. Phosphaturic mesenchymal tumors. A polymorphous group causing osteomalacia or rickets. Cancer 1987;59:1442-54.
  • 10 Gonzalez-Compta X, Mañós-Pujol M, Foglia-Fernandez M, Peral E, Condom E, Claveguera T, et al. Oncogenic osteomalacia: Case report and review of head and neck associated tumours. J Laryngol Otol 1998;112:389-92.
  • 11 Jan de Beur SM, Streeten EA, Civelek AC, McCarthy EF, Uribe L, Marx SJ, et al. Localisation of mesenchymal tumours by somatostatin receptor imaging. Lancet 2002;359:761-3.
  • 12 Avila NA, Skarulis M, Rubino DM, Doppman JL. Oncogenic osteomalacia: Lesion detection by MR skeletal survey. AJR Am J Roentgenol 1996;167:343-5.