Subscribe to RSS
![](/products/assets/desktop/img/oa-logo.png)
DOI: 10.4103/JLP.JLP_97_17
Internal quality control of blood products: An experience from a tertiary care hospital blood bank from Southern Pakistan
Financial support and sponsorship: Nil![](https://www.thieme-connect.de/media/10.1055-s-00044881/201801/lookinside/thumbnails/10-4103-jlp-jlp-97-17_064-1.jpg)
Abstract
INTRODUCTION: Internal quality control (IQC) is the backbone of quality assurance program. In blood banking, the quality control of blood products ensures the timely availability of a blood component of high quality with maximum efficacy and minimal risk to potential recipients. The main objective of this study is to analyze the IQC of blood products as an indicator of our blood bank performance.
METHODS: An observational cross-sectional study was conducted at the blood bank of Liaquat National Hospital and Medical College, from January 2014 to December 2015. A total of 100 units of each blood components were arbitrarily chosen during the study. Packed red cell units were evaluated for hematocrit (HCT); random platelet concentrates were evaluated for pH, yield, and culture; fresh frozen plasma (FFP) and cryoprecipitate (CP) were evaluated for unit volume, factor VIII, and fibrinogen concentrations.
RESULTS: A total of 400 units were tested for IQC. The mean HCT of packed red cells was 69.5 ± 7.24, and in 98% units, it met the standard (<80% of HCT). The mean platelet yield was 8.8 ± 3.40 × 109/L and pH was ≥6.2 in 98% bags; cultures were negative in 97% of units tested. Mean factor VIII and fibrinogen levels were found to be 84.24 ± 15.01 and 247.17 ± 49.69 for FFP, respectively. For CP, mean factor VIII and fibrinogen level were found to be 178.75 ± 86.30 and 420.7 ± 75.32, respectively.
CONCLUSION: The IQC of blood products at our blood bank is in overall compliance and met recommended international standards. Implementation of standard operating procedures, accomplishment of standard guidelines, proper documentation with regular audit, and staff competencies can improve the quality performance of the transfusion services.
Publication History
Received: 24 May 2017
Accepted: 24 August 2017
Article published online:
19 February 2020
© 2018.
Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India
-
References
- 1 Bolton-Maggs PH, Cohen H. Serious Hazards of Transfusion (SHOT) haemovigilance and progress is improving transfusion safety. Br J Haematol 2013;163:303-14.
- 2 Xu GP, Wu LF, Li JJ, Gao Q, Liu ZD, Kang QH, et al. Performance assessment of internal quality control (IQC) products in blood transfusion compatibility testing in China. PLoS One 2015;10:e0141145.
- 3 Yu Y, Ma C, Feng Q, Chen X, Guan X, Zhang X, et al. Establishment and performance assessment of preparation technology of internal quality control products for blood transfusion compatibility testing. Exp Ther Med 2013;5:1466-70.
- 4 Franchini M, Capuzzo E, Turdo R, Glingani C. Quality of transfusion products in blood banking. Semin Thromb Hemost 2014;40:227-31.
- 5 Liumbruno G, D'Amici GM, Grazzini G, Zolla L. Transfusion medicine in the era of proteomics. J Proteomics 2008;71:34-45.
- 6 Sultan S, Murad S, Irfan SM, Biag MA. Trends of venereal infections among healthy blood donors at Karachi. Arch Iran Med 2016;19:192-6.
- 7 Zaheer HA, Waheed U. Blood transfusion service in disasters. Transfus Apher Sci 2016;55:186-90.
- 8 Components from whole blood donations. Technical Manual, American Association of Blood Banking (AABB). 2005. 15th ed. p. 202.
- 9 Sultan S, Baig MA, Irfan SM, Ahmed SI, Hasan SF. Adverse reactions in allogeneic blood donors: A tertiary care experience from a developing country. Oman Med J 2016;31:124-8.
- 10 Kim DU. The quest for quality blood banking program in the new millennium the American way. Int J Hematol 2002;76 Suppl 2:258-62.
- 11 Ferreira AM, Brener S, de Carvalho RV, do Valle MC, Moraes-Souza H. Participation in proficiency programs and promotion of quality in transfusion services of Minas Gerais. Rev Bras Hematol Hemoter 2012;34:21-4.
- 12 Coêlho MJ, Monteiro Tde C, Vasquez FG, Silva KL, Dos Santos KS, de Oliveira VM, et al. Platelet aggregation and quality control of platelet concentrates produced in the amazon blood bank. Rev Bras Hematol Hemoter 2011;33:110-4.
- 13 Tudisco C, Jett BW, Byrne K, Oblitas J, Leitman SF, Stroncek DF. The value of pH as a quality control indicator for apheresis platelets. Transfusion 2005;45:773-8.
- 14 Levin E, Jenkins C, Culibrk B, Gyöngyössy-Issa MI, Serrano K, Devine DV. Development of a quality monitoring program for platelet components: A report of the first four years' experience at Canadian Blood Services. Transfusion 2012;52:810-8.
- 15 Fasola FA, Okunade MA, Abjah UM. Quality assessment of platelet concentrate prepared at a tertiary centre in Nigeria. Afr J Med Med Sci 2002;31:337-9.
- 16 Standards and Guidelines for Blood Banks and Transfusion. Safe Blood Transfusion Programm- SBTP. 1st ed. Islamabad: Government of Pakistan; 2013. p. 22-3