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CC BY-NC-ND 4.0 · J Lab Physicians 2019; 11(03): 281-283
DOI: 10.4103/JLP.JLP_172_18
Case Report

Plasma cell neoplasm with varied morphology: A report of two cases

Gautam Kumar Vasnik
Department of Pathology, Military Hospital, Nasirabad, Rajasthan, India
,
S. Venkatesan
Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India
,
Sanjeevan Sharma
Department of Hematology, Command Hospital (SC), Pune, Maharashtra, India
,
Ajay Malik
Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India
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Abstract

Plasma cell (PC) neoplasm (PCN) with varied morphology has been described in the literature. The majority of clonal proliferation of PCs is composed of easily recognizable morphology in the bone marrow (BM). However, few cases may cause diagnostic complexity, as they exhibit varied cytological and architectural heterogeneity which may pose problem in morphological diagnosis and require the use of ancillary techniques like immunohistochemistry (IHC). We illustrate here two such cases of PCN with varied morphology in BM aspirate, in the form of clustering/rosetting and multiple clear cytoplasmic vacuoles, respectively, leading to varied differential diagnosis. However, later, the histopathological features on BM biopsy findings were relatively characteristic and IHC confirmed the final diagnosis. The morphological variants documented in both these cases are exceptional and representative of the various forms of atypical PCs.

Key words

Bone marrow - immunohistochemistry - morphology - plasma cell neoplasm


Publication History

Received: 28 December 2018

Accepted: 31 May 2019

Article published online:
07 April 2020

© 2019.

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