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CC BY-NC-ND 4.0 · J Lab Physicians 2018; 10(02): 248-250
DOI: 10.4103/JLP.JLP_167_16
Case Report

Well differentiated papillary mesothelioma of abdomen- a rare case with diagnostic dilemma

Aniruddha Saha
Anandaloke Sonoscan Centre, Siliguri, West Bengal, India
,
Palash Kumar Mandal
Department of Pathology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India
,
Anupam Manna
Anandaloke Sonoscan Centre, Siliguri, West Bengal, India
,
Kalyan Khan
Department of Pathology, North Bengal Medical College, Siliguri, West Bengal, India
,
Subrata Pal
Department of Pathology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India
› Author Affiliations Financial support and sponsorship Nil
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Abstract

Well-differentiated papillary mesothelioma is a rare tumor occurring predominantly in the peritoneum of young women, a few with history of asbestos exposure. A 28-year-old woman presented with ascites and pain abdomen. Ultrasonography and computed tomography scan of the abdomen revealed a mass in the retroperitoneum measuring 15 cm × 12 cm. Histopathological examination along with immunohistochemistry (IHC) confirmed it to be a papillary mesothelioma in the peritoneum. It is difficult to differentiate from more common malignant mesothelioma and papillary adenocarcinoma, which also have poorer prognosis. The difficulty can be resolved by clinico-radiological correlation along with histopathological examination and IHC.

Keywords

Immunohistochemistry - peritoneum - well-differentiated papillary mesothelioma


Publication History

Received: 19 December 2016

Accepted: 13 November 2017

Article published online:
19 February 2020

© 2018.

Thieme Medical and Scientific Publishers Private Ltd.
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  • References

  • 1 Goepel JR. Benign papillary mesothelioma of peritoneum: A histological, histochemical and ultrastructural study of six cases. Histopathology 1981;5:21-30.
  • 2 Daya D, McCaughey WT. Well-differentiated papillary mesothelioma of the peritoneum. A clinicopathologic study of 22 cases. Cancer 1990;65:292-6.
  • 3 Goldblum J, Hart WR. Localized and diffuse mesotheliomas of the genital tract and peritoneum in women. A clinicopathologic study of nineteen true mesothelial neoplasms, other than adenomatoid tumors, multicystic mesotheliomas, and localized fibrous tumors. Am J Surg Pathol 1995;19:1124-37.
  • 4 Butnor KJ, Sporn TA, Hammar SP, Roggli VL. Well-differentiated papillary mesothelioma. Am J Surg Pathol 2001;25:1304-9.
  • 5 Diaz LK, Okonkwo A, Solans EP, Bedrossian C, Rao MS. Extensive myxoid change in well-differentiated papillary mesothelioma of the pelvic peritoneum. Ann Diagn Pathol 2002;6:164-7.
  • 6 Hammar SP, Bockus DE, Remington FL, Rohrbach KA. Mucin-positive epithelial mesotheliomas: A histochemical, immunohistochemical, and ultrastructural comparison with mucin-producing pulmonary adenocarcinomas. Ultrastruct Pathol 1996;20:293-325.
  • 7 Comin CE, Saieva C, Messerini L. H-caldesmon, calretinin, estrogen receptor, and ber-EP4: A useful combination of immunohistochemical markers for differentiating epithelioid peritoneal mesothelioma from serous papillary carcinoma of the ovary. Am J Surg Pathol 2007;31:1139-48.