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CC BY-NC-ND 4.0 · J Lab Physicians 2019; 11(03): 244-248
DOI: 10.4103/JLP.JLP_163_18
Original Article

Single point insulin sensitivity estimator as an index for insulin sensitivity for metabolic syndrome: A study in North Indian population

Parmila Dudi
Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Bela Goyal
Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Vartika Saxena
Department of Community and Family Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Kamlesh Rabari
Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Anissa Atif Mirza
Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Manisha Naithani
Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Tarun Kumar
Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Rajeev Goyal
Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India
› Author Affiliations Financial support and sponsorship We acknowledge financial support from AIIMS, Rishikesh, through intramural project (Reference No. IEC/IM/05/RC/04).
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Abstract

BACKGROUND: Various indices for estimating insulin sensitivity, based on glucose tolerance test and fasting insulin levels, have been devised. However, they are laborious, time-consuming, and costly. Recently, a new index, single point insulin sensitivity estimator (SPISE) based on TG, high-density lipoproteins (HDL), and body mass index (BMI) was proposed in the European population and was found comparable to gold standard test. Decreased insulin sensitivity is a hallmark of metabolic syndrome (MetS). Hence, the current study was planned to determine the optimal cutoff of SPISE with high sensitivity and specificity in MetS patients of the North Indian population.

MATERIALS AND METHODS: A community-based cross-sectional study including 229 MetS cases and 248 controls was conducted. MetS was defined according to the South Asian Modified National Cholesterol Education Program criteria. SPISE index was calculated for cases and controls using the formula devised by Paulmichl et al.: SPISE = 600 × HDL-C0.185/(TG0.2 × BMI1.338). Receiver operating characteristic (ROC) curve was plotted for determining optimal cutoff for SPISE in MetS.

RESULTS: SPISE was significantly lower in MetS patients (5.35 ± 1.35) than that for controls (7.45 ± 2) with P < 0.05 (confidence interval [CI]: 1.79—2.41). ROC curve showed area under the curve = 0.83 for SPISE (P < 0.05, CI: 0.79—0.86), showing SPISE to have good predictive ability to discriminate MetS cases from controls. The cutoff value of SPISE index for predicting insulin sensitivity in MetS was found out to be 5.82 with sensitivity and specificity of 73% and 80%, respectively. This cutoff is lower than the European population (6.61), indicating higher insulin resistance (IR) in the study population.

CONCLUSION: SPISE could be a useful potential low-cost indicator with high sensitivity and specificity for predicting IR in MetS.

Key words

Insulin resistance - metabolic syndrome - single point insulin sensitivity estimator


Publication History

Received: 03 December 2018

Accepted: 11 June 2019

Article published online:
07 April 2020

© 2019.

Thieme Medical and Scientific Publishers Private Ltd.
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