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CC BY-NC-ND 4.0 · J Lab Physicians 2018; 10(03): 316-319
DOI: 10.4103/JLP.JLP_144_17
Original Article

Systemic inflammatory response markers in preeclampsia

Ersin Çintesun
Department of Obstetrics and Gynecology, Selcuk Universit Konya, Turkey
,
Feyza Nur Incesu Çintesun
Department of Obstetrics and Gynecology, Konya Training and Research Hospital Konya, Turkey
,
Huriye Ezveci
Department of Obstetrics and Gynecology, Selcuk Universit Konya, Turkey
,
Fikret Akyürek
Department of Biochemistry, Selçuk University, Konya, Turkey
,
Çetin Çelik
Department of Obstetrics and Gynecology, Selcuk Universit Konya, Turkey
› Author Affiliations Financial support and sponsorship: Nil
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ABSTRACT

PURPOSE: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), platelet distribution width (PDW), red cell distribution width (RDW), mean platelet volume (MPV), and plateletcrit (PCT) are known as systemic inflammatory response markers. In this study, we aimed to evaluate changes in NLR, PLR, PDW, RDW, MPV, and PCT in preeclampsia (PE) and their use in predicting its severity.

MATERIALS AND METHODS: This is a retrospective case–control study. The study comprised 64 control group (healthy pregnant females), 51 females with mild PE, and 13 with severe PE. These three groups were compared with demographic data and inflammation markers.

RESULTS: There were no statistically significant differences between healthy pregnant females and preeclaptic females in terms of median age, hemoglobin, lymphocyte, neutrophil, platelet, NLR, PLR, PDV, RDW, MPV, PCT (P > 0.05). The control group has a higher number of gravity and parity than the PE group (P < 0.001). MPV value is a lower PE group than the control group (P < 0.001). Both gravity and parity were significantly higher in the patients with mild PE than in the control group (P < 0.001). MPV value was statistically higher in the control group compared both mild and severe PE (P < 0.001), however, no statistical difference between mild and severe PE (P = 0.305).

CONCLUSIONS: MPV may be clinically useful markers in the prediction of PE. Further, prospective multicenter studies are needed to reveal the association between these markers and PE.

Keywords

Inflammatory - lymphocyte - neutrophil - platelet - preeclampsia


Publication History

Received: 12 September 2017

Accepted: 28 November 2017

Article published online:
19 February 2020

© 2018.

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