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CC BY-NC-ND 4.0 · J Lab Physicians 2019; 11(02): 103-106
DOI: 10.4103/JLP.JLP_141_18
Original Article

M2G1G2 white blood cell flag by three-part automated hematology analyzer: A hint to dengue infection in appropriate clinical context

Maitrayee Roy
Department of Pathology, M.M. Institute of Medical Sciences and Research, Ambala, Haryana, India
,
Akshay Bali
Department of Hematology, Maitri Diagnostic Lab, Ambala, Haryana, India
› Author Affiliations Financial support and sponsorship: Nil.
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Abstract

BACKGROUND: Automated hematology analyzers often generate many flags which can provide important clues to the underlying hematological abnormality. Although pathologists are generally well versed in recognizing the importance of flags indicating potential leukemic blasts, their utility in hinting toward infectious etiology, especially during epidemics, is less well known. We analyzed any abnormal flags generated by a three-part automated hematology analyzer in serologically confirmed cases of dengue.

MATERIALS AND METHODS: The study included 28 patients diagnosed with serologically confirmed dengue infection. The venous samples were run on ABX Miros-60 three-part hematology analyzer. The complete blood count data and any abnormal flags were noted and correlated with peripheral blood film findings in all patients.

RESULTS: An abnormal white blood cell (WBC) flag was noted in all 28 patients, including two in whom all other hematological parameters were within normal limits. In 26 (93%) patients, M2G1G2 WBC flag was noted while the samples of the remaining two patients generated M2G1 and L1M2G1G2 WBC flags, respectively.

CONCLUSION: An abnormal WBC flag, when correlated in appropriate clinical context, especially during a dengue outbreak, can aid in targeting the cohort of patients who will require immediate referral for serological confirmation.

Key words

Dengue - M2G1G2 white blood cell flag - three-part hematology analyzer


Publication History

Received: 20 October 2018

Accepted: 22 March 2019

Article published online:
06 April 2020

© 2019.

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