A clinical and microbiological study to evaluate the effect of dietary supplement of coenzyme Q10 in nonsurgical treatment outcome of chronic periodontitis patients after phase 1 periodontal therapy

Abstract

Aim: The present study was aimed to evaluate the effect of dietary supplement of coenzyme Q10 (CoQ10) in nonsurgical treatment outcome of chronic periodontitis patients after phase 1 periodontal therapy. Materials and Methods: A total of 50 generalized chronic periodontitis patient between the aged ranges between 18 and 55 years were enrolled in the study and divided into two categories (A and B). Clinical and microbiological parameters were recorded prior to phase 1 therapy; and subjects were put on conventional oral hygiene regime. The subjects under group B were incorporated with CoQ10 as nutritional dietary supplement (TDS). Results: The results of this study showed that there was significant decrease in clinical and microbiological parameters from baseline to 4 months in both groups (P < 0.01). The subjects under group B incorporated with dietary supplement of CoQ10 showed a highly significant reduction to all the parameters when compared to subjects under group A. Conclusion: Long-term regular intake of nutritional dietary supplement of CoQ10 is more beneficial in nonsurgical treatment outcome of periodontal disease.

Keywords

Coenzyme Q10 - periodontitis - ubiquinone

Publication History

Article published online:
01 November 2021

• References

• 1 Saini R, Saini S, Saini SR. Periodontitis: A risk for delivery of premature labor and low birth weight infants. J Nat Sci Biol Med 2011;2:50-2.
• 2 Saini R. Dental Air Force home dental cleaning system: A revolutionary oral hygiene device to prevent systemic diseases caused by periodontal infection. Int J Med Res Health Sci 2013;2:431-8.
• 3 Saini R. Coenzyme Q10: The essential nutrient. J Pharm Bioallied Sci 2011;3:466-7.
• 4 Saini R. Vitamins and periodontitis. J Pharm Bioallied Sci 2011;3:170.
• 5 Battino M, Ferreiro MS, Bompadre S, Leone L, Mosca F, Bullon P. Elevated hydroperoxide levels and antioxidant patterns in Papillon-Lefèvre syndrome. J Periodontol 2001;72:1760-6.
• 6 Battino M, Bullon P, Wilson M, Newman H. Oxidative injury and inflammatory periodontal diseases: The challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med 1999;10:458-76.
• 7 Saini R, Saini S, Sharma S. Antioxidants accelerates cellular health. Int J Green Pharm 2010;3:212.
• 8 Prakash S, Sunitha J, Hans M. Role of coenzyme Q (10) as an antioxidant and bioenergizer in periodontal diseases. Indian J Pharmacol 2010;42:334-7.
• 9 Nakamura R, Littarru GP, Folkers K, Wilkinson EG. Deficiency of coenzyme Q in gingiva of patients with periodontal disease. Int J Vitam Nutr Res 1973;43:84-92.
• 10 Littarru GP, Nakamura R, Ho L, Folkers K, Kuzell WC. Deficiency of coenzyme Q 10 in gingival tissue from patients with periodontal disease. Proc Natl Acad Sci U S A 1971;68:2332-5.
• 11 Wilkinson EG, Arnold RM, Folkers K, Hansen I, Kishi H. Bioenergetics in clinical medicine. II. Adjunctive treatment with coenzyme Q in periodontal therapy. Res Commun Chem Pathol Pharmacol 1975;12:111-23.
• 12 Nakamura R, Littarru GP, Folkers K, Wilkinson EG. Study of CoQ10-enzymes in gingiva from patients with periodontal disease and evidence for a deficiency of coenzyme Q10. Proc Natl Acad Sci U S A 1974;71:1456-60.
• 13 Shizukuishi S, Hanioka T, Tsunemitsu A, Fukunaga Y, Kishi T, Sato N. Clinical effect of coenzyme 10 on periodontal disease; evaluation of oxygen utilization in gingiva by tissue reflectance spectrophotometry. In: Shizukuishi S, Hanioka T, Tsunemitsu A, editors. Biomedical and Clinical Aspects of Coenzyme Q. Vol. 5. Amsterdam: Elsevier; 1986. p. 359-68.
• 14 McRee JT, Hanioka T, Shizukuishi S, Folkers K. Therapy with Coenzyme Q10 for patients with periodontal disease. 1. Effect of Coenzyme Q10 on subgingival micro-organisms. J Dent Health 1993;43:659-66.
• 15 AR Gaby. The role of CoQ10 in clinical medicine: Part 1. Altern Med Rev 1996;1:11-7.
• 16 Wilkinson EG, Arnold RM, Folkers K. Bioenergetics in clinical medicine. VI. adjunctive treatment of periodontal disease with coenzyme Q10. Res Commun Chem Pathol Pharmacol 1976;14:715-9.