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CC BY-NC-ND 4.0 · European Journal of General Dentistry 2012; 1(03): 142-147
DOI: 10.4103/2278-9626.105354
Review Article

Additive and synergistic effect of phytochemicals in prevention of oral cancer

Sunira Chandra
Department of Oral Medicine & Radiology, Teerthanker Mahaveer Dental College and Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India
,
Kunal Sah
1   Department of Oral Pathology & Microbiology, Teerthanker Mahaveer Dental College and Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India
,
Anjana Bagewadi
2   Department of Oral Medicine and Radiology, VK KLES Institute of Dental Sciences, KLE University Belgaum, Karnataka, India
,
Vaishali Keluskar
2   Department of Oral Medicine and Radiology, VK KLES Institute of Dental Sciences, KLE University Belgaum, Karnataka, India
,
Arvind Shetty
2   Department of Oral Medicine and Radiology, VK KLES Institute of Dental Sciences, KLE University Belgaum, Karnataka, India
,
Renuka Ammanagi
2   Department of Oral Medicine and Radiology, VK KLES Institute of Dental Sciences, KLE University Belgaum, Karnataka, India
,
Zameera Naik
2   Department of Oral Medicine and Radiology, VK KLES Institute of Dental Sciences, KLE University Belgaum, Karnataka, India
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Abstract

Increasing the consumption of fruits, vegetables, and whole grains is a practical strategy to optimize good health and to reduce the risk of various chronic diseases and cancer. There are approximately 5,000 individual phytochemicals which have been identified. These interfere with multiple important cellular pathways and play an important role in maintaining balance between health and disease. This article aims to provide awareness of various additive and synergistic effects of these natural occurring chemical substances (phytochemicals) found in various fruits and vegetables. Their mechanism of action in preventing various chronic diseases and cancer is also been highlighted in this article. Grouping plant foods by color provides simplification, but it is also important as a method to help consumer′s make-wise food choices and promote health. We believe phytochemicals can be best acquired through whole-food consumption and not through the pills or an extracts.

Keywords

Cancer - chronic diseases - color - fruits - health - phytochemicals - vegetables


Publikationsverlauf

Artikel online veröffentlicht:
01. November 2021

© 2012. European Journal of General Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Heber D, Bowerman S. Applying sciences to changing dietary patterns. J Nutr 2011;131:3078-81S.
  • 2 Temple NJ. Antioxidants and disease: More questions than answers. Nutr Res 2000;20:449-59.
  • 3 Willett WC. Diet and health: What should we eat? Science 1994;254:532-7.
  • 4 Willett WC. Diet, nutrition, and avoidable cancer. Environ Health Perspect 1995;103 (Suppl 8) :165-70.
  • 5 Liu RH. Health benefits of fruits and vegetables are from additive and synergistic combination of phytochemicals. Am J Clin Nutr 2003;78:517-20S.
  • 6 Craig WJ. Phytochemicals: Guardians of our health. J Am Diet Assoc 1997;97 (10 Suppl 2) :S199-204.
  • 7 Caragay AB. Cancer-preventative foods and ingredients. Food Technol 1992;46:65-8.
  • 8 Liu RH, Hotchkiss JH. Potential genotoxicity of chronically elevated nitric oxide: A review. Mutat Res 1995;339:73-89.
  • 9 Ames BN, Gold LS. Endogenous mutagens and the causes of aging and cancer. Mutat Res 1991;250:3-16.
  • 10 Ames BN, Shigenaga MK, Gold LS. DNA lesions, inducible DNA repair, and cell division: The three key factors in mutagenesis and carcinogenesis. Environ Health Perspect 1993;101 (Suppl 5) :35-44.
  • 11 Liu RH. Potential synergy of phytochemicals in cancer prevention: Mechanism of action. J Nutr 2004;134 (12 Suppl) :3479S-85.
  • 12 National Academy of Sciences, Committee on Diet and Health, National Research Council. Diet and Health: Implications for Reducing Chronic Disease Risk. Washington, DC: National Academy Press; 1989.
  • 13 Sun J, Chu YF, Wu X, Liu RH. Antioxidant and anti-proliferative activities of fruits. J Agric Food Chem 2002;50:7449-54.
  • 14 Chu YF, Sun J, Wu X, Liu RH. Antioxidant and antiproliferative activities of vegetables. J Agric Food Chem 2002;50:6910-6.
  • 15 Hollman PC, Arts IC. Flavonols, flavones and flavanols-nature, occurrence and dietary burden. J Sci Food Agric 2000;80:1081-93.
  • 16 Kanner J, Frankel E, Granit R, German B, Kinsella JE. Natural antioxidants in grapes and wines. J Agric Food Chem 1994;42:64-9.
  • 17 Demrow HS, Slane PR, Folts JD. Administration of wine and grape juice inhibits in vivo platelets activity and thrombosis in stenosed canine coronary arteries. Circulation 1995;91:1182-8.
  • 18 Kinsella JE, Frankel E, German B, Kanner J. Possible mechanisms for protective role of antioxidants in wine and plant foods. Food Technol 1993;47:85-9.
  • 19 Adom KK, Liu RH. Antioxidant activity of grains. J Agric Food Chem 2002;50:6182-7.
  • 20 Dewanto V, Wu X, Liu RH. Processed sweet corn has higher antioxidant activity. J Agric Food Chem 2002;50:4959-64.
  • 21 Kohimeier L, Hastings SB. Epidemiologic evidence of a role of carotenoids in cardiovascular disease prevention. Am J Clin Nutr 1995;62 (6 Suppl) :1370S-6.
  • 22 Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med 2004;50:145-9.
  • 23 Heber D, Bowerman S. What color is your diet? New York: Harper Collins/Regan; 2011.
  • 24 Talalay P, Fahey JW. Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr 2001;131 (11 Suppl) :3027S-33.
  • 25 National Academy of Sciences. Diet, Nutrition and Cancer. Washington, DC: National Academy Press; 1982.
  • 26 National Academy of Sciences. Diet and Health. Implications for Reducing Chronic Disease Risk. Washington, DC: National Academy Press; 1989.
  • 27 World Cancer Research Fund and American Institute for Cancer Research. Food, Nutrition, and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research; 1997.
  • 28 Steinmetz KA, Potter JD. Vegetables, fruit and cancer. I. Epidemiology. Cancer Causes Control 1991;2:325-57.
  • 29 Steinmetz KA, Potter JD. Vegetables, fruit and cancer. II. Mechanisms. Cancer Causes Control 1991;2:427-42.
  • 30 Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: A review. J Am Diet Assoc 1996;96:1027-39.
  • 31 Bidlack WR, Omaye ST, Meskin MS, Topham DK. Phytochemicals as Bioactive Agents. Lancaster, PA: Technomic Publishing Company; 2000.
  • 32 Torrance CJ, Jackson PE, Montgomery E, Kinzler KW, Vogelstein B, Wissner A, et al. Combinatorial chemoprevention of intestinal neoplasia. Nat Med 2000;6:1024-8.
  • 33 Brenner DE. Multiagent chemopreventative agent combinations. J Cell Biochem Suppl 2000;34:121-4.
  • 34 Dragsted LO, Strube M, Larsen JC. Cancer-protective factors in fruits and vegetables: Biochemical and biological background. Pharmacol Toxicol 1993;72 (Suppl 1) :116-35.
  • 35 Waladkhani AR, Clemens MR. Effect of dietary phytochemicals on cancer development (review). Int J Mol Med 1998;1:747-53.
  • 36 Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr Cancer 1992;18:1-29.
  • 37 Knekt P, Järvinen R, Seppänen R, Hellövaara M, Teppo L, Pukkala E, et al. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 1997;146:223-30.
  • 38 Le Marchand L, Murphy SP, Hankin JH, Wilkens LR, Kolonel LN. Intake of flavonoids and lung cancer. J Natl Cancer Inst 2000;92:154- 60.