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CC BY-NC-ND 4.0 · South Asian J Cancer 2014; 03(01): 043-047
DOI: 10.4103/2278-330X.126520
FEMALE REPRODUCTIVE TRACT TUMORS : Original Article

Serum zinc as a prognostic indicator in locally advanced cancer cervix patients receiving chemo-irradiation: A pilot study

Vivek Tiwari
Department of Radiation Oncology, Artemis Health Institute, Sector 51, Gurgaon, Haryana
,
Piyush Shukla
Department of Radiation Oncology, Artemis Health Institute, Sector 51, Gurgaon, Haryana
,
Gourav Gupta
Department of Radiation Oncology, Artemis Health Institute, Sector 51, Gurgaon, Haryana
› Author Affiliations Source of Support: Nill.
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Abstract

Objective: To evaluate the prognostic significance of serum Zinc (S.Zn) in locally advanced cancer cervix (LACC) patients treated with chemo-irradiation. Materials and Methods: S.Zn values in 34 females with histopathologically (HP) proven LACC (>/= stage II B) were prospectively measured using atomic absorption spectrophotometer pre- and post-treatment. Thirty-four age- and sex-matched healthy individuals were also evaluated for the parameter during the course of the study. After completion of treatment, the patients were divided into 2 groups based on the response, 1 - Complete response (CR) and 2 - Partial/No response (PR/NR). These groups were compared based on the observations of the studied parameter. Results: The mean post-treatment S.Zn values were significantly higher in group 1 as compared to group 2 (P < 0.05). Conclusion: In our study, patients achieving CR had higher mean levels of S.Zn compared to patients achieving PR/NR. We advocate further in-depth studies to evaluate the role of S.Zn in the prognosis of LACC patients treated with chemo-irradiation.

Key words

Cancer cervix - chemo-irradiation - serum zinc


Publication History

Article published online:
31 December 2020

© 2014. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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