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CC BY-NC-ND 4.0 · South Asian J Cancer 2012; 01(02): 76-77
DOI: 10.4103/2278-330X.103717
Original Article

Fluoride levels and osteosarcoma

Simmi Kharb
Departments of Biochemistry, Pt.BDS PGIMS, Rohtak, India
,
Ravindra Sandhu
Departments of Biochemistry, Pt.BDS PGIMS, Rohtak, India
,
Zile Singh Kundu
Departments of Orthopedics, Pt.BDS PGIMS, Rohtak, India
› Author Affiliations Source of Support: Nil.
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Abstract

Context: Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma. Aims: The present study was planned to analyze serum levels of fluoride in patients of osteosarcoma and fluoride content of their drinking water. Settings and Design: The present study was carried out comparing 10 patients of osteosarcoma and 10 healthy volunteers (who served as controls). Materials and Methods: Serum and drinking water fluoride levels were estimated by ion selective electrode. Statistical analysis used: The data were computed as mean ± SD and Student’s t test was applied. Results: Both, the serum and drinking water fluoride levels, were significant by higher in patients with osteosarcoma as compared to controls (P < 0.05, P < 0.001, respectively). Conclusions: These results suggest a link between fluoride exposure and osteosarcoma.

Key words

Fluoride - osteosarcoma - serum - water


Publication History

Article published online:
30 December 2020

© 2012. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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