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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2013; 05(02): 52-61
DOI: 10.4103/1947-489X.210527
Article

Adiponectin and adiponectin receptor-1 in patients with polycystic ovarian syndrome: Impact of insulin sensitization by metformin

Manal Kamal
1   Department of Physiology, College of Medicine, Qassim University, Saudi Arabia and Assiut University, Assiut, Egypt
,
Hossam Hamed
2   Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Saudi Arabia and Assiut University, Assiut, Egypt
,
Ragaa Salama
3   Department of Biochemistry, College of Medicine, Qassim University, Saudi Arabia and Assiut University, Assiut, Egypt
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Background: Abdominal obesity, insulin resistance and hyperinsulinemia play a central role in the pathogenesis of polycystic ovarian syndrome (PCOS). Abdominal adipose tissue is a source of adiponectin. Metformin has been widely used in the treatment of PCOS and has been shown to improve the metabolic and hormonal disturbances of PCOS. Objective: The current study aimed to investigate the relationships between serum adiponectin and adiponec-tin receptor-1 (AdipoR1) with insulin resistance, hormonal variables, and anthropometric measures in patients with polycystic ovarian syndrome (PCOS), and to find the shortterm effect of metformin treatment on adiponectin and Adi-poR-1 levels in these patients. Patients and Methods: 38 PCOS patients and 14 age- and body mass index (BMI)-matched healthy controls were recruited. In all participants, BMI, waist circumference, serum levels of fasting glucose, insulin, adiponectin, AdipoR1, total testosterone, luteiniz-ing hormone (LH), and follicle stimulating hormone (FSH) were assessed. PCOS patients received metformin treatment (1500 mg/daily) for two menstrual cycles followed by measurement of all previous parameters. All subjects gave informed consent. Results: PCOS patients had higher waist circumference, fasting glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), testosterone, LH and LH/FSH ratio than did controls. In PCOS patients, adiponectin and AdipoR1 were lower than in controls, and both correlated negatively with waist circumference, insulin, and HOMA-IR (P=0.048, P=0.0003, P=0.0003, respectively for adiponectin and P=0.039, P=0.023, P=0.025, respectively for AdipoR-1). HOMA-IR followed by testosterone were independent predictors of adiponectin while HOMA-IR was an independent predictor of AdipoR1. Metformin decreased fasting glucose (P=0.003), insulin (P=0.042), HOMA-IR (P=0.006), testosterone (P=0.001), LH (P=0.0001) and LH/ FSH ratio (P=0.003) and increased adiponectin (P=0.014) and AdipoR1 (P=0.001) levels in PCOS patients. Conclusion: Reduced adiponectin and Ad-sipoR1 in PCOS patients is independently associated with insulin resistance and the improvement of insulin sensitivity by short-term metformin treatment results in increased adiponectin and AdipoR-l.

Key-words:

Adiponectin - Adiponectin receptor - Metfor-min - Polycystic ovarian syndrome.


Publication History

Received: 25 July 2012

Accepted: 15 September 2012

Article published online:
07 July 2022

© 2013. The Libyan Authorityof Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is givenappropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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