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CC BY-NC-ND 4.0 · Asian J Neurosurg 2017; 12(02): 283-286
DOI: 10.4103/1793-5482.146390
CASE REPORT

Granulomatous hypophysitis caused by Rathke's cleft cyst mimicking a growth hormone-secreting pituitary adenoma

Masato Hojo
Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507
,
Ryota Ishibashi
Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507
,
Hiroshi Arai
1   Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507
,
Susumu Miyamoto
Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507
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We report a case of granulomatous hypophysitis caused by Rathke's cleft cyst (RCC) mimicking a growth hormone (GH)-secreting pituitary adenoma. Neuroradiological and endocrinological evaluations showed abnormal findings consistent with acromegaly: Magnetic resonance imaging demonstrated a pituitary mass lesion, and GH and insulin-like growth factor I levels were markedly elevated, and GH levels were not suppressed in oral glucose tolerance test. Transsphenoidal surgery was performed, but no adenomatous tissue could be detected. Histological examination revealed RCC and concurrent granulomatous giant cell inflammatory reaction of the anterior hypophysis. To the authors' knowledge, this is the first documented case of granulomatous hypophysitis caused by RCC mimicking a GH-secreting pituitary adenoma.

Key-words:

Acromegaly - granulomatous hypophysitis - growth hormone - insulin-like growth factor I - Rathke′s cleft cyst


Publication History

Article published online:
20 September 2022

© 2017. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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