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CC BY-NC-ND 4.0 · World J Nucl Med 2014; 13(01): 50-55
DOI: 10.4103/1450-1147.138575
Original article

Comparative Study of Radionuclide Uptake Levels between Primary and Metastatic Bone Tumors

Yigbedeck Huguette
1   Department of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, Accra, Ghana
,
Kyere Kwame
1   Department of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, Accra, Ghana
,
Wilson Kojo
2   Department of Nuclear Medicine, National Centre for Radiotherapy and Nuclear Medicine, Korle-Bu Teaching Hospital, Accra, Ghana
,
Hasford Francis
1   Department of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, Accra, Ghana
3   Medical Radiation Physics Centre, Radiological and Medical Sciences Research Institute, Ghana Atomic Energy Commission, Accra, Ghana
,
Sosu Kwabla
1   Department of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, Accra, Ghana
3   Medical Radiation Physics Centre, Radiological and Medical Sciences Research Institute, Ghana Atomic Energy Commission, Accra, Ghana
,
Ankrah Otoe
2   Department of Nuclear Medicine, National Centre for Radiotherapy and Nuclear Medicine, Korle-Bu Teaching Hospital, Accra, Ghana
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Study on 95 patients to compare radionuclide uptake levels in patients undergoing bone scintigraphy at a Nuclear Medicine Unit has been performed quantitatively using Image J software. Patients were administered with activity ranging from 0.555 to 1.110 MBq depending on their body weight, and their whole-body bone scans obtained with an installed e.cam single-photon emission computed tomography system. Matrix size of 256 × 1024 was used in acquiring the scintigrams. Quantitative analyses performed with installed Image J software revealed higher radionuclide uptake levels in metastatic tumors compared with primary tumors for all selected skeletal parts. Average normalized count of activity in metastatic tumors was 37.117 ± 27.740 cts/mm 2 /MBq and its corresponding uptake in primary tumors was 23.035 ± 19.542 cts/mm 2 /MBq. The relative higher uptake in metastatic tumors over primary tumors could be attributed to higher osteoblastic activity and blood flow in metastatic tumors.

Keywords

Counts of activity - diagnosis - metastatic tumor - primary tumor - quantitative assessments - radionuclide - scintigraphy - single-photon emission computed tomography - therapeutic


Publication History

Article published online:
23 May 2022

© 2014. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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