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CC BY-NC-ND 4.0 · Journal of Digestive Endoscopy 2016; 07(02): 071-073
DOI: 10.4103/0976-5042.189156
Case Report
Journal of Digestive Endoscopy

Plummer-Vinson syndrome presenting as squamous cell carcinoma of esophagus

Gandhi Lanke
Department of Gastroenterology, Hepatology and Nutrition, University of Texas MD Anderson Cancer Center, Houston,
,
Pramoda Koduru
1   Department of Internal Medicine, Texas Tech University, Odessa, Texas, USA
,
Manoop S. Bhutani
1   Department of Internal Medicine, Texas Tech University, Odessa, Texas, USA
› Author Affiliations
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Publication History

Publication Date:
26 September 2019 (online)

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Abstract

Plummer-Vinson syndrome (PVS) also known as Paterson-Brown-Kelly syndrome is a rare syndrome which comprises iron deficiency anemia, dysphagia, and esophageal webs. The pathogenesis of PVS is not clear. Iron deficiency anemia is essential for diagnosis of PVS. If left untreated, there is an increased risk of developing pharyngeal or esophageal cancer in about 10% of patients. There are no strict guidelines for endoscopic surveillance in patients with PVS. Iron replacement can improve dysphagia and potentially lead to regression of esophageal webs. In this case report, we present a patient who had long-standing dysphagia for years which progressed to squamous cell cancer of esophagus by the time she sought medical treatment.

Key words

Dysphagia - esophageal cancer - iron deficiency anemia - Paterson-Brown-Kelly syndrome,
 

  • References

  • 1 Chen TS, Chen PS. Rise and fall of the Plummer-Vinson syndrome. J Gastroenterol Hepatol 1994;9:654-8.
  • 2 Chisholm M. The association between webs, iron and post-cricoid carcinoma. Postgrad Med J 1974;50:215-9.
  • 3 Bredenkamp JK, Castro DJ, Mickel RA. Importance of iron repletion in the management of Plummer-Vinson syndrome. Ann Otol Rhinol Laryngol 1990;99:51-4.
  • 4 Okamura H, Tsutsumi S, Inaki S, Mori T. Esophageal web in Plummer-Vinson syndrome. Laryngoscope 1988;98:994-8.
  • 5 Novacek G. Plummer-Vinson syndrome. Orphanet J Rare Dis 2006;1:36.
  • 6 Dinler G, Tander B, Kalayci AG, Rizalar R. Plummer-Vinson syndrome in a 15-year-old boy. Turk J Pediatr 2009;51:384-6.
  • 7 Hoffman RM, Jaffe PE. Plummer-Vinson syndrome. A case report and literature review. Arch Intern Med 1995;155:2008-11.
  • 8 Makharia GK, Nandi B, Garg PK, Tandon RK. Plummer Vinson syndrome: Unusual features. Indian J Gastroenterol 2002;21:74-5.
  • 9 Park JM, Kim KO, Park CS, Jang BI. A case of plummer-vinson syndrome associated with Crohn’s disease. Korean J Gastroenterol 2014;63:244-7.
  • 10 Jessner W, Vogelsang H, Püspök A, Ferenci P, Gangl A, Novacek G, et al. Plummer-Vinson syndrome associated with celiac disease and complicated by postcricoid carcinoma and carcinoma of the tongue. Am J Gastroenterol 2003;98:1208-9.
  • 11 Owen RD. The problem of hypopharyngeal carcinoma. J Laryngol Otol 1950;64:434-49.
  • 12 Shamma’a MH, Benedict EB. Esophageal webs; a report of 58 cases & an attempt at classification. N Engl J Med 1958;259:378-84.
  • 13 Jones RF. The Paterson-Brown Kelly syndrome. Its relationship to iron deficiency and postcricoid carcinoma. II. J Laryngol Otol 1961;75:544-61.
  • 14 Chisholm M, Ardran GM, Callender ST, Wright R. A follow-up study of patients with post-cricoid webs. Q J Med 1971;40:409-20.
  • 15 Sreenivas DV, Kumar A, Mannar KV, Babu GR. Results of Savary-Gilliard dilatation in the management of cervical web of esophagus. Hepatogastroenterology 2002;49:188-90.