CC BY-NC-ND 4.0 · Journal of Digestive Endoscopy 2016; 07(01): 001-005
DOI: 10.4103/0976-5042.180084
Review Article
Society of Gastrointestinal Endoscopy of India

Refractory benign esophageal strictures

Gopal Goyal
Department of Gastroenterology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India
,
Surender Sultania
Department of Gastroenterology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India
,
Babulal Meena
Department of Gastroenterology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India
,
Sandeep Nijhawan
Department of Gastroenterology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India
› Author Affiliations
Further Information

Publication History

Publication Date:
26 September 2019 (online)

Abstract

Refractory benign esophageal stricture (RBES) is a frequently encountered problem worldwide. These strictures arise from various causes such as corrosive injury, radiation therapy, peptic origin, ablative therapy, and after surgery. Most strictures can be treated successfully with endoscopic dilatation using bougies or balloons, with only a few complications. Those patients who fail after serial dilatation with bougies or balloons will come to the category of refractory strictures. Dilatation combined with intralesional steroid injections can be considered for peptic strictures, whereas incisional therapy has been demonstrated to be effective for short anastomotic strictures. When these therapeutic options do not resolve the stenosis, stent placement should be considered. Self-bougienage can be proposed to a selected group of patients with a proximal stenosis. Most of the patients of RBES respond to above-mentioned treatment and occasional patient may require surgery as the final treatment option. This review aims to provide a comprehensive approach toward endoscopic management of RBESs based on current literature and personal experience.

 
  • References

  • 1 Siersema PD. Treatment options for esophageal strictures. Nat Clin Pract Gastroenterol Hepatol 2008;5:142-52.
  • 2 Hirdes MM, Vleggaar FP, Siersema PD. Stent placement for esophageal strictures: An update. Expert Rev Med Devices 2011;8:733-55.
  • 3 Patterson DJ, Graham DY, Smith JL, Schwartz JT, Alpert E, Lanza FL, et al. Natural history of benign esophageal stricture treated by dilatation. Gastroenterology 1983;85:346-50.
  • 4 Williamson RC. The management of peptic oesophageal stricture. Br J Surg 1975;62:448-54.
  • 5 Broor SL, Kumar A, Chari ST, Singal A, Misra SP, Kumar N, et al. Corrosive oesophageal strictures following acid ingestion: Clinical profile and results of endoscopic dilatation. J Gastroenterol Hepatol 1989;4:55-61.
  • 6 Kochman ML, McClave SA, Boyce HW. The refractory and the recurrent esophageal stricture: A definition. Gastrointest Endosc 2005;62:474-5.
  • 7 Lahoti D, Broor SL, Basu PP, Gupta A, Sharma R, Pant CS. Corrosive esophageal strictures: Predictors of response to endoscopic dilation. Gastrointest Endosc 1995;41:196-200.
  • 8 Rana SS, Bhasin DK, Singh K. Role of endoscopic ultrasonography (EUS) in management of benign esophageal strictures. Ann Gastroenterol 2011;24:280-284.
  • 9 Riley SA, Attwood SE. Guidelines on the use of oesophageal dilatation in clinical practice. Gut 2004;53 Suppl 1:i1-6.
  • 10 Ramage JI Jr., Rumalla A, Baron TH, Pochron NL, Zinsmeister AR, Murray JA, et al. A prospective, randomized, double-blind, placebo-controlled trial of endoscopic steroid injection therapy for recalcitrant esophageal peptic strictures. Am J Gastroenterol 2005;100:2419-25.
  • 11 Dunne D, Rupp T, Rex D. Five year follow up of prospective randomized trial of savory dilations with or without intralesional steroids of benign gastroesophageal reflux strictures. Gastroenterology 1999;116:A152.
  • 12 Hirdes MM, van Hooft JE, Koornstra JJ, Timmer R, Leenders M, Weersma RK, et al. Endoscopic corticosteroid injections do not reduce dysphagia after endoscopic dilation therapy in patients with benign esophagogastric anastomotic strictures. Clin Gastroenterol Hepatol 2013;11:795-801.
  • 13 Kochhar R, Ray JD, Sriram PV, Kumar S, Singh K. Intralesional steroids augment the effects of endoscopic dilation in corrosive esophageal strictures. Gastrointest Endosc 1999;49 (4 Pt 1):509-13.
  • 14 Kochhar R, Makharia GK. Usefulness of intralesional triamcinolone in treatment of benign esophageal strictures. Gastrointest Endosc 2002;56:829-34.
  • 15 Camargo MA, Lopes LR, Grangeia Tde A, Andreollo NA, Brandalise NA. Use of corticosteroids after esophageal dilations on patients with corrosive stenosis: Prospective, randomized and double-blind study. Rev Assoc Med Bras 2003;49:286-92.
  • 16 Hordijk ML, Siersema PD, Tilanus HW, Kuipers EJ. Electrocautery therapy for refractory anastomotic strictures of the esophagus. Gastrointest Endosc 2006;63:157-63.
  • 17 Song HY, Jung HY, Park SI, Kim SB, Lee DH, Kang SG, et al. Covered retrievable expandable nitinol stents in patients with benign esophageal strictures: Initial experience. Radiology 2000;217:551-7.
  • 18 Eloubeidi MA, Lopes TL. Novel removable internally fully covered self-expanding metal esophageal stent: Feasibility, technique of removal, and tissue response in humans. Am J Gastroenterol 2009;104:1374-81.
  • 19 Kim JH, Song HY, Choi EK, Kim KR, Shin JH, Lim JO. Temporary metallic stent placement in the treatment of refractory benign esophageal strictures: Results and factors associated with outcome in 55 patients. Eur Radiol 2009;19:384-90.
  • 20 Bakken JC, Wong Kee Song LM, de Groen PC, Baron TH. Use of a fully covered self-expandable metal stent for the treatment of benign esophageal diseases. Gastrointest Endosc 2010;72:712-20.
  • 21 Eloubeidi MA, Talreja JP, Lopes TL, Al-Awabdy BS, Shami VM, Kahaleh M. Success and complications associated with placement of fully covered removable self-expandable metal stents for benign esophageal diseases (with videos). Gastrointest Endosc 2011;73:673-81.
  • 22 Hirdes MM, Siersema PD, Vleggaar FP. A new fully covered metal stent for the treatment of benign and malignant dysphagia: A prospective follow-up study. Gastrointest Endosc 2012;75:712-8.
  • 23 Repici A, Hassan C, Sharma P, Conio M, Siersema P. Systematic review: The role of self-expanding plastic stents for benign oesophageal strictures. Aliment Pharmacol Ther 2010;31:1268-75.
  • 24 Ham YH, Kim GH. Plastic and biodegradable stents for complex and refractory benign esophageal strictures. Clin Endosc 2014;47:295-300.
  • 25 Broto J, Asensio M, Vernet JM. Results of a new technique in the treatment of severe esophageal stenosis in children: Poliflex stents. J Pediatr Gastroenterol Nutr 2003;37:203-6.
  • 26 Evrard S, Le Moine O, Lazaraki G, Dormann A, El Nakadi I, Devière J. Self-expanding plastic stents for benign esophageal lesions. Gastrointest Endosc 2004;60:894-900.
  • 27 Repici A, Conio M, De Angelis C, Battaglia E, Musso A, Pellicano R, et al. Temporary placement of an expandable polyester silicone-covered stent for treatment of refractory benign esophageal strictures. Gastrointest Endosc 2004;60:513-9.
  • 28 Triester SL, Fleischer DE, Sharma VK. Failure of self-expanding plastic stents in treatment of refractory benign esophageal strictures. Endoscopy 2006;38:533-7.
  • 29 Barthel JS, Kelley ST, Klapman JB. Management of persistent gastroesophageal anastomotic strictures with removable self-expandable polyester silicon-covered (Polyflex) stents: An alternative to serial dilation. Gastrointest Endosc 2008;67:546-52.
  • 30 Dua KS, Vleggaar FP, Santharam R, Siersema PD. Removable self-expanding plastic esophageal stent as a continuous, non-permanent dilator in treating refractory benign esophageal strictures: A prospective two-center study. Am J Gastroenterol 2008;103:2988-94.
  • 31 Martin RC, Woodall C, Duvall R, Scoggins CR. The use of self-expanding silicone stents in esophagectomy strictures: Less cost and more e-ciency. Ann Thorac Surg 2008;86:436-40.
  • 32 García-Cano J. Dilation of benign strictures in the esophagus and colon with the polyflex stent: A case series study. Dig Dis Sci 2008;53:341-6.
  • 33 Karbowski M, Schembre D, Kozarek R, Ayub K, Low D. Polyflex self-expanding, removable plastic stents: Assessment of treatment e-cacy and safety in a variety of benign and malignant conditions of the esophagus. Surg Endosc 2008;22:1326-33.
  • 34 Oh YS, Kochman ML, Ahmad NA, Ginsberg GG. Clinical outcomes after self-expanding plastic stent placement for refractory benign esophageal strictures. Dig Dis Sci 2010;55:1344-8.
  • 35 van Boeckel PG, Vleggaar FP, Siersema PD. A comparison of temporary self-expanding plastic and biodegradable stents for refractory benign esophageal strictures. Clin Gastroenterol Hepatol 2011;9:653-9.
  • 36 Canena JM, Liberato MJ, Rio-Tinto RA, Pinto-Marques PM, Romão CM, Coutinho AV, et al. A comparison of the temporary placement of 3 different self-expanding stents for the treatment of refractory benign esophageal strictures: A prospective multicentre study. BMC Gastroenterol 2012;12:70.
  • 37 Repici A, Vleggaar FP, Hassan C, van Boeckel PG, Romeo F, Pagano N, et al. E-cacy and safety of biodegradable stents for refractory benign esophageal strictures: The BEST (biodegradable esophageal stent) study. Gastrointest Endosc 2010;72:927-34.
  • 38 Tanaka T, Takahashi M, Nitta N, Furukawa A, Andoh A, Saito Y, et al. Newly developed biodegradable stents for benign gastrointestinal tract stenoses: A preliminary clinical trial. Digestion 2006;74:199-205.
  • 39 Saito Y, Tanaka T, Andoh A, Minematsu H, Hata K, Tsujikawa T, et al. Usefulness of biodegradable stents constructed of poly-l-lactic acid monofilaments in patients with benign esophageal stenosis. World J Gastroenterol 2007;13:3977-80.
  • 40 Saito Y, Tanaka T, Andoh A, Minematsu H, Hata K, Tsujikawa T, et al. Novel biodegradable stents for benign esophageal strictures following endoscopic submucosal dissection. Dig Dis Sci 2008;53:330-3.
  • 41 van Hooft JE, van Berge Henegouwen MI, Rauws EA, Bergman JJ, Busch OR, Fockens P. Endoscopic treatment of benign anastomotic esophagogastric strictures with a biodegradable stent. Gastrointest Endosc 2011;73:1043-7.
  • 42 Hirdes MM, Siersema PD, van Boeckel PG, Vleggaar FP. Single and sequential biodegradable stent placement for refractory benign esophageal strictures: A prospective follow-up study. Endoscopy 2012;44:649-54.
  • 43 Karakan T, Utku OG, Dorukoz O, Sen I, Colak B, Erdal H, et al. Biodegradable stents for caustic esophageal strictures: A new therapeutic approach. Dis Esophagus 2013;26:319-22.