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CC BY-NC-ND 4.0 · Journal of Digestive Endoscopy 2015; 06(01): 029-031
DOI: 10.4103/0976-5042.155251
Case Report
Society of Gastrointestinal Endoscopy of India

Sarcoidosis presenting as acute pancreatitis

Vishal Sharma
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh
,
Surinder S. Rana
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh
,
Vinita Chaudhary
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh
,
Ravi K. Sharma
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh
,
Uma Nahar
1   Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh
,
Dheeraj Gupta
2   Department of Pulmonary Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh
,
Usha Dutta
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh
,
Deepak K. Bhasin
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh
› Author Affiliations
Further Information

Publication History

Publication Date:
26 September 2019 (online)

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Abstract

Hypercalcemic states may result in acute pancreatitis. Sarcoidosis has been rarely reported as a cause of acute pancreatitis. A 42-year-old female came with abdominal pain and was found to have acute pancreatitis. Evaluation revealed hypercalcemia and evidence of pulmonary infiltrates and mediastinal lymphadenopathy. Transbronchial lung biopsy revealed noncaseating granulomas consistent with sarcoidosis. In conclusion, sarcoidosis may result in acute pancreatitis by causing hypercalcemia.

Key words

Acute pancreatitis - bronchoscopy - granuloma - hypercalcemia - hyperparathyroidism - sarcoidosis - steroids
 

  • References

  • 1 Ebert EC, Kierson M, Hagspiel KD. Gastrointestinal and hepatic manifestations of sarcoidosis. Am J Gastroenterol 2008;103:3184-92.
  • 2 Shukla M, Hassan MF, Toor V, Kaur J, Solomon C, Cohen H. Symptomatic pancreatic sarcoidosis. Case report and review of literature. JOP 2007;8:770-4.
  • 3 Gupta D, Agarwal R, Singh A, Joshi K. A "respiratory" cause of abdominal pain. Eur Respir J 2006;27:430-3.
  • 4 Sharma SK, Mohan A, Guleria R, Padhy AK. Diagnostic dilemma: Tuberculosis? or, sarcoidosis? Indian J Chest Dis Allied Sci 1997;39:119-23.
  • 5 Peters MJ, Jones MG, Moulton J, Breslin AB. Sarcoidosis presenting as recurrent alcohol-induced pancreatitis. Med J Aust 1990;153:104-5.
  • 6 Boruchowicz A, Wallaert B, Cortot A, Bouault JM, Paris JC, Colombel JF. Idiopathic acute pancreatitis and sarcoidosis. Gastroenterol Clin Biol 1995;19:439-41.
  • 7 Karnchanasorn R, Sarikonda M, Aldasouqi S, Gossain VV. Severe hypercalcemia and acute renal failure: An unusual presentation of sarcoidosis. Case Rep Med 2010;2010:423659.
  • 8 Poornachandra KS, Bhasin DK, Nagi B, Sinha SK, Rana SS, Shafiq N, et al. Clinical, biochemical, and radiologic parameters at admission predicting formation of a pseudocyst in acute pancreatitis. J Clin Gastroenterol 2011;45:159-63.
  • 9 Dazai Y, Katoh I, Hara Y, Yoshida R, Kurihara K. Two cases of adult T-cell leukemia associated with acute pancreatitis due to hypercalcemia. Am J Med 1991;90:251-4.
  • 10 Biondi A, Persiani R, Marchese M, Cananzi F, D′Ugo D. Acute pancreatitis associated with primary hyperparathyroidism. Updates Surg 2011;63:135-8.
  • 11 Frick TW. The role of calcium in acute pancreatitis. Surgery 2012;152:S157-63.
  • 12 Bhadada SK, Udawat HP, Bhansali A, Rana SS, Sinha SK, Bhasin DK. Chronic pancreatitis in primary hyperparathyroidism: Comparison with alcoholic and idiopathic chronic pancreatitis. J Gastroenterol Hepatol 2008;23:959-64.
  • 13 Bhasin DK, Rana SS, Chandail VS, Singh G, Gupta R, Kang M, et al. Clinical profile of calcific and noncalcific chronic pancreatitis in north India. J Clin Gastroenterol 2011;45:546-50.
  • 14 Frick TW, Mithöfer K, Fernández-del Castillo C, Rattner DW, Warshaw AL. Hypercalcemia causes acute pancreatitis by pancreatic secretory block, intracellular zymogen accumulation, and acinar cell injury. Am J Surg 1995;169:167-72.