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DOI: 10.4103/0971-5851.125245
Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India
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Abstract
Objective: Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface markers involved with respect to disease surveillance thereby highlighting it as a strong prognostic marker for future diagnosis and treatment. Materials and Methods: A total of 500 consecutively selected ALL patients were diagnosed and treated according to National Cancer Institute protocol (MCP 841) for a period of 24-88 months during this hospital-based study. Results: Of the total, 50.4% had a higher incidence of T-ALL and 47.6% had pro-B, B-cell precursor ALL. Disease free survival and event free survival were remarkably higher in B-ALL adolescent patients as compared to T-ALL, who had significantly lower overall survival ratio. Prevalence of T-ALL was also observed in relapse cases for adolescent patients. Conclusions: We conclude that there is an increased prevalence of T-ALL among adolescents in Eastern India. Immunophenotypic analysis might help in proper evaluation and prediction of treatment outcomes with an increased thrust on studying age-specific incident rates enabling well planned future treatments for improved and better outcome.
Keywords
Acute lymphoblastic leukemia - B-acute lymphoblastic leukemia - immunophenotype - prognostic marker - T-acute lymphoblastic leukemiaPublication History
Article published online:
19 July 2021
© 2013. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)
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References
- 1 Ribera JM, Oriol A. Acute lymphoblastic leukemia in adolescents and young adults. Hematol Oncol Clin North Am 2009;23(5):1033-42, vi.
- 2 Jameson JN St C, Dennis LK, Harrison TR, Braunwald E, Fauci AS, Hauser SL, Longo DL. Harrison′s principles of internal medicine. New York: McGraw-Hill Medical Publishing Division; 2005.
- 3 Greaves MF, Colman SM, Beard ME, Bradstock K, Cabrera ME, Chen PM, et al. Geographical distribution of acute Lymphoblastic Leukemia subtype: Second report of collaborative group study. Leukemia 1993;7:27-34.
- 4 Jackson AL, Warner NL. Preparation, staining, and analysis by flow cytometry of peripheral blood leukocytes. In: Manual of Clinical Laboratory Immunology. 3 rd ed. Washington, DC: ASM Press; 1986.
- 5 Raje NS, Vaidya SJ, Kapoor G, Pai SK, Nair CN, Kurkure PA, et al. Low incidence of CNS relapse with cranial radiotherapy and intrathecal methotrexate in Acute lymphoblastic leukemia. Indian pediatrics 1996;33:556-60.
- 6 Onciu M, Lai R, Vega F, Bueso-Ramos C, Medeiros LJ. Precursor T-cell acute lymphoblastic leukemia in adults: age-related immunophenotypic, cytogenetic, and molecular subsets. Am J Clin Pathol 2002;117(2):252-8.
- 7 Brunning RD, Borowitz M, Matutes E. Precursor B-cell and T-cell neoplasms. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2001.
- 8 Bhargava M, Kumar R, Karak A, Kochupillai V, Arya LS, Mohanakumar T. Immunological subtypes of acute lymphoblastic leukemia in India. Leuk Res 1988;12:673-8.
- 9 Rajalekshmy KR, Abitha AR, Anuratha N, Sagar TG. Time trend in frequency of occurrence of major immunophenotypes in paediatric acute lymphoblastic leukemia cases as experienced by Cancer Institute, Chennai, south India during the period 1989-2009. Indian J Cancer 2011;48:310-5.