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DOI: 10.4103/0971-3026.120253
MRI brain in monohalomethane toxic encephalopathy: A case report
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Abstract
Monohalomethanes are alkylating agents that have been used as methylating agents, laboratory reagents, refrigerants, aerosol propellants, pesticides, fumigants, fire-extinguishing agents, anesthetics, degreasers, blowing agents for plastic foams, and chemical intermediates. Compounds in this group are methyl chloride, methyl bromide, methyl iodide (MI), and methyl fluoride. MI is a colorless volatile liquid used as a methylating agent to manufacture a few pharmaceuticals and is also used as a fumigative insecticide. It is a rare intoxicant. Neurotoxicity is known with both acute and chronic exposure to MI. We present the characteristic magnetic resonance imaging (MRI) brain findings in a patient who developed neuropsychiatric symptoms weeks after occupational exposure to excessive doses of MI.
Publication History
Article published online:
30 July 2021
© 2013. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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References
- 1 Ehler E, Latta J, Eichlerová A, Mrklovský M, Urban P. Exposure to iodomethane and dichloromethane associated with a confusional state. Neurotoxicology 2011;32:307-11.
- 2 Nair JR, Chatterjee K. Methyl iodide poisoning presenting as a mimic of acute stroke: A case report. J Med Case Rep 2010;4:177.
- 3 Appel GB, Galen R, O′Brien J, Schoenfeldt R. Methyl iodide intoxication. A case report. Ann Intern Med 1975;82:534-6.
- 4 Hermouet C, Garnier R, Efthymiou M, Fournier P. Methyl iodide poisoning: Report of two cases. Am J Ind Med 1996;30:759-64.
- 5 Schwartz MD, Obamwonyi AO, Thomas JD, Moorhead JF, Morgan BW. Acute methyl iodide exposure with delayed neuropsychiatric sequelae: Report of a case. Am J Ind Med 2005;47:550-6.
- 6 Geyer HL, Schaumburg HH, Herskovitz S. Methyl bromide intoxication causes reversible symmetric brainstem and cerebellar MRI lesions. Neurology 2005;64;1279-81.
- 7 Ichikawa H, Sakai T, Horibe Y, Kaga E, Kawamura M. A case of chronic methyl bromide intoxication showing symmetrical lesions in the basal ganglia and brain stem on magnetic resonance imaging. Rinsho Shinkeigaku 2001;41:423-7.
- 8 Suwanlaong K, Phanthumchinda K. Neurological Manifestation of Methyl Bromide Intoxication. Kanokrat Suwanlaong, Kammant Phanthumchinda. J Med Assoc Thai 2008;91:421-6.
- 9 Hyakudo T, Hori H, Tanaka I, Igisu H. Inhibition of creatine kinase activity in rat brain by methyl bromide gas. Inhal Toxicol 2001;13:659-69.
- 10 Baselt R. Disposition of Toxic Drugs and Chemicals in Man, 2 nd ed. Davis, California: Biochemical Publications; 1982. p. 516-7.
- 11 Gosselin RE, Smith RP, Hodge HC. Clinical toxicology of commercial products. 5 th ed. Philadelphia: William and Wilkins; 1984. p. III-280, III-284, II-158.
- 12 Cavanagh JB. Methyl bromide intoxication and acute energy deprivation syndromes. Neuropathol Appl Neurobiol 1992;18:575-8.
- 13 Zhong C, Jin L, Fei G. MR Imaging of Nonalcoholic Wernicke Encephalopathy: A Follow-Up Study. AJNR Am J Neuroradiol 2005;26:2301-5.
- 14 Kim E, Na DG, Kim EY, Kim JH, Son KR, Chang KH. MR imaging of metronidazole-induced encephalopathy: Lesion distribution and diffusion-weighted imaging findings. Am J Neuroradiol 2007;28:1652-8.
- 15 Shen WC, Chiu HH, Chow KC, Tsai CH. MR Imaging findings of enteroviral encephalomyelitis: An outbreak in Taiwan. AJNR Am J Neuroradiol 1999;20:1889-95.