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DOI: 10.3233/JPN-2009-0299
Fetal brain disruption sequence in surviving co-twins
Subject Editor:
Publication History
04 August 2008
11 October 2008
Publication Date:
30 July 2015 (online)
Abstract
Two male infants who were both survivors of monochorionic twin pregnancies in which there was intrauterine demise of one twin are described. These infants had features of microcephaly associated with radiologic features of porencephaly, hydranencephaly and microcranium. The diagnosis assigned was severe fetal brain disruption sequence. Both infants had severe developmental delay and one infant died suddenly at age 7 months. A comparison is made with previously reported cases. The diagnosis of fetal brain disruption sequence should be entertained in infants with severe congenital microcephaly with overlapping sutures associated with scalp rugae and should be anticipated in twin pregnancies in which there has been demise of one co-twin during the second trimester.