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DOI: 10.3233/JPI-2010-0228
NOx as new targets of treatment in influenza-associated encephalopathy
Verantwortlicher Herausgeber dieser Rubrik:
Publikationsverlauf
07. September 2008
14. Mai 2009
Publikationsdatum:
28. Juli 2015 (online)
Abstract
The number of children with a new type of influenza-associated encephalopathy is increasing in Japan on a nationwide scale. It is associated with a high mortality rate of approximately 30% and there are no efficient treatments. Approximately half of the patients have sequelae despite anti-cytokine therapies. Severe cases showed high levels of free radicals in serum and cerebrospinal fluid, and previous studies suggest that free-radical scavengers may be effective to reduce sequelae. We presented two cases where a new radical scavenger, edaravone, was administered in addition to anti-cytokine therapies and reviewed our findings in the context of previously published papers.