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DOI: 10.1590/0004-282X20200015
Hippocampal sclerosis in paracoccidioidomycosis
Esclerose hipocampal na paracoccidioidomicose![](https://www.thieme-connect.de/media/10.1055-s-00054595/202006/lookinside/thumbnails/10-1590-0004-282x20200015_20200015-1.jpg)
A 39-year-old man presented with complex partial seizures five years after treatment of central nervous system (CNS) paracoccidioidomycosis (PCM). Post-treatment images showed reduction of the CNS lesions and appearance of hippocampal sclerosis (HS) ([Figures 1] and [2]). To the best of our knowledge, this is the first description between PCM and HS.
![](https://www.thieme-connect.de/media/10.1055-s-00054595/202006/thumbnails/10-1590-0004-282x20200015-i20200015-1.jpg)
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![](https://www.thieme-connect.de/media/10.1055-s-00054595/202006/thumbnails/10-1590-0004-282x20200015-i20200015-2.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)
HS is a common pathological finding in temporal lobe epilepsy[1]. The etiology is controversial, whether acquired or developmental, however triggering factors of HS can be epilepticus status, febrile seizures, infectious and vascular diseases or malformations. When associated with other diseases, as in this case of PCM[2],[3], it is called dual pathology.
Publication History
Received: 08 January 2020
Accepted: 27 January 2020
Article published online:
13 June 2023
© 2020. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Liu Z, Mikati M, Holmes GL. Mesial temporal sclerosis: pathogenesis and significance. Pediatr Neurol. 1995 Jan;12(1):5-16. https://doi.org/10.1016/0887-8994(94)00122-i
- 2 Rosa Júnior M, Baldon IV, Amorim AC, Melo AFC, Peçanha P, Falqueto A, et al. Imaging paracoccidioidomycosis: A pictorial review from head to toe. Eur J Radiol. 2018 Jun;103:147-62. https://doi.org/10.1016/j.ejrad.2018.03.026
- 3 Rosa Júnior M, Amorim AC, Baldon IV, Martins RM, Pereira RP, Campos SS, et al. Paracoccidioidomycosis of the Central Nervous System: CT and MR imaging findings. AJNR Am J Neuroradiol. 2019 Oct;40(10):1681-8. https://doi.org/10.3174/ajnr.A6203