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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2018; 76(01): 32-40
DOI: 10.1590/0004-282X20170182
ARTICLE

Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats

Timoquinona protegeu contra deficiências de aprendizagem e memória e danos nos tecidos cerebrais em ratos hipotireoidais juvenis
Yousef Baghcheghi
1   Mashhad University of Medical Sciences, Faculty of Medicine, Department of Physiology, Student Research Committee, Mashhad, Iran;
,
Mahmoud Hosseini
2   Mashhad University of Medical Sciences, Psychiatry and Behavioral Sciences Research Center, Division of Neurocognitive Sciences, Mashhad, Iran;
,
Farimah Beheshti
3   Torbat Heydariyeh University of Medical Sciences, Department of Basic Science and Neuroscience Research Center, Torbat Heydariyeh, Iran;
,
Hossein Salmani
4   Mashhad University of Medical Sciences, Faculty of Medicine, Department of Physiology, Mashhad, Iran;
,
Akbar Anaeigoudari
5   Jiroft University of Medical Sciences, School of Medicine, Department of Physiology, Jiroft, Iran.
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ABSTRACT

In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg/kg and 10 mg/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats.

RESUMO

Neste estudo, foi investigado o efeito da timoquinona (TQ) contra deficiências de memória induzidas por propiltiouracilo (PTU) em ratos juvenis. Os ratos foram agrupados em grupos: controle, Hypo, Hypo-TQ5, e Hypo-TQ10. O PTU aumentou o tempo de latência no teste do labirinto aquático de Morris (MWM) e diminuiu o atraso para entrar no compartimento escuro no teste de evasão passiva (PA). Ambas as doses de TQ diminuíram o tempo de latência no teste de MWM e aumentaram o atraso para entrar no compartimento escuro no teste de PA. O PTU também aumentou os metabolitos de malondialdeído (MDA) e óxido nítrico (NO) no cérebro, enquanto reduziu o teor de tiol e as atividades de superóxido dismutasa (SOD) e catalasa (CAT) e o nível sérico de T4. Ambas as doses de TQ diminuíram os metabolitos de MDA e de NO no cérebro, aumentaram o conteúdo de tiol e as atividades de SOD e CAT e o nível de T4 no soro. Os resultados do presente estudo mostraram que a TQ protegeu contra deficiências de memória induzidas por PTU em ratos.

hypothyroidism - propylthiouracil - memory
hipotireoidismo - propiltiouracila - memória

Support:

Jiroft University of Medical Sciences.




Publication History

Received: 06 June 2017

Accepted: 29 September 2017

Article published online:
30 August 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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