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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2017; 75(11): 773-777
DOI: 10.1590/0004-282X20170146
Article

Impact of disease duration on functional status of patients with spinocerebellar ataxia type 2

Repercussões do tempo de evolução sobre o perfil funcional de pacientes com ataxia espinocerebelar do tipo 2
Thiago R. Padilha Amarante
1   Universidade Federal do Paraná, Programa de Residência Integrada Multiprofissional em Cuidados Hospitalares - Saúde para Adultos e Idosos, Curitiba PR, Brasil;
,
Sibele Y. M. Takeda
2   Universidade Federal do Paraná, Departamento de Prevenção e Reabilitação de Fisioterapia, Curitiba PR, Brasil;
,
Hélio A. G. Teive
3   Universidade Federal do Paraná, Hospital de Clínicas, Departamento de Medicina Interna, Curitiba PR, Brasil;
4   Universidade Federal do Paraná, Unidade dos Distúrbios do Movimento, Curitiba PR, Brasil
,
Marise Bueno Zonta
1   Universidade Federal do Paraná, Programa de Residência Integrada Multiprofissional em Cuidados Hospitalares - Saúde para Adultos e Idosos, Curitiba PR, Brasil;
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ABSTRACT

Objective: To correlate disease duration in spinocerebellar ataxia type 2 (SCA2) with disease severity, balance and functionality.

Method: Sixteen SCA2 patients were analyzed for: disease duration, disease severity (SARA score), balance (Berg balance scale score) and functionality (FIM and Lawton scores).

Results: Greater severity was correlated with worse functionality (Lawton: r = −0.0561, FIM: r = −0.6402) and balance (r = −0.7188). Longer disease duration was correlated with greater severity (p = 0.0002) and reduced functionality (FIM: p = 0.005; Lawton: p = 0.0402) and balance (p = 0.0036). A year increase in disease duration corresponded to a 0.8-point increase on the SARA scale, a 1.38-point decrease in FIM score, a 2.30-point decrease on the Berg balance scale and a 0.45-point decrease on the Lawton scale.

Conclusion: Longer disease duration in this series of SCA2 patients was correlated with greater disease severity, worse balance and greater functional dependency.

RESUMO

Objetivo: Correlacionar com o tempo de evolução da doença em pacientes com ataxia espinocerebelar do tipo 2 (SCA2) com a gravidade, equilíbrio e funcionalidade.

Método: Foram considerados dados de 16 indivíduos: tempo de evolução, nível de gravidade (SARA) e escores de equilíbrio (BERG) e funcionalidade (MIF e LAWTON).

Resultados: A maior gravidade esteve relacionada aos piores escores de funcionalidade (LAWTON: r = −0,0561, MIF: r = −0,6402) e de equilíbrio (r = −0,7188). O maior tempo de evolução esteve relacionado à maior gravidade (p = 0,0002) e menor funcionalidade (MIF: p = 0,005; Lawton (p = 0,0402) e equilíbrio (p = 0,0036) sendo que para o aumento de um ano no tempo de evolução, espera-se um aumento de 0,8 pontos no escore da SARA, e decréscimo de 1,38 pontos na MIF, 2,30, na Berg e 0,45 na Lawton.

Conclusão: O tempo de evolução dos sintomas está associado a maior gravidade da doença, pior equilíbrio e maior dependência funcional em pacientes comSCA2.

Keywords:

spinocerebellar ataxias - severity of illness index - postural balance

Palavras-chave:

ataxia espinocerebelar - índice de gravidade da doença - equilíbrio postural


Publication History

Received: 24 March 2017

Accepted: 04 August 2017

Article published online:
01 September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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