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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2016; 74(03): 253-255
DOI: 10.1590/0004-282X20160035
VIEW AND REVIEW

Guillain-Barré syndrome associated with the Zika virus outbreak in Brazil

Síndrome de Guillain-Barré associada ao surto de infecção por vírus Zika no Brasil
Lucas Masiêro Araujo
1   Universidade Federal Fluminense, Departamento de Medicina Interna Neurology, Rio de Janeiro RJ, Brazil;
,
Maria Lucia Brito Ferreira
2   Hospital da Restauração, Divisão de Neurologia, Recife PE, Brazil.
,
Osvaldo JM Nascimento
1   Universidade Federal Fluminense, Departamento de Medicina Interna Neurology, Rio de Janeiro RJ, Brazil;
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ABSTRACT

Zika virus (ZIKV) is now considered an emerging flavivirosis, with a first large outbreak registered in the Yap Islands in 2007. In 2013, a new outbreak was reported in the French Polynesia, with associated cases of neurological complications including Guillain-Barré syndrome (GBS). The incidence of GBS has increased in Brazil since 2015, what is speculated to be secondary to the ZIKV infection outbreak. The gold-standard test for detection of acute ZIKV infection is the polymerase-chain reaction technique, an essay largely unavailable in Brazil. The diagnosis of GBS is feasible even in resource-limited areas using the criteria proposed by the GBS Classification Group, which is based solely on clinical grounds. Further understanding on the relationship of ZIKV with neurological complications is a research urgency.

RESUMO

O vírus Zika (VZIK) é agora considerado uma flavivirose emergente, com um primeiro grande surto registrado nas ilhas Yap, em 2007. Em 2013, novo surto foi registado na Polinésia francesa, com complicações neurológicas, incluindo a síndrome de Guillain-Barré (SGB). A incidência de SGB experimentou um aumento durante o ano de 2015, o que se especula ser secundário ao surto de infecção pelo ZIKV. A técnica em reação em cadeia de polimerase é considerado o teste padrão-ouro, mas é pouco disponível no Brasil. O diagnóstico da SGB é possível mesmo em áreas com recursos limitados usando os critérios propostos pelo GBS Classificati on Group, os quais são baseados exclusivamente em achados clínicos. Um maior entendimento da relação entre a infecção pelo ZIKV e complicações neurológicas é uma urgência de pesquisa.

Guillain-Barre syndrome - GBS - Zika virus - Zika virus infection outbreak - neurological complications
Síndrome de Guillain-Barré - SGB - vírus Zika - complicações neurológicas


Publication History

Received: 30 December 2015

Accepted: 02 March 2016

Article published online:
06 September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Musso D, Cao-Lormeau VM, Gubler DJ. Zika virus: following the path of dengue and chikungunya? Lancet. 2015;386(9990):243-4. doi:10.1016/S0140-6736(15)61273-9
  • 2 Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009;360(24):2536-43. doi:10.1056/NEJMoa0805715
  • 3 European Centre for Disease Prevention and Control. Rapid risk assessment: Zika virus infection outbreak, French Polynesia: 14 February 2014. Stockhom: European Centre for Disease Prevention and Control; 2014 [cited 2015 Dec 22]. Available from: http://ecdc.europa.eu/en/publications/Publications/Zika-virus-French-Polynesia-rapid-risk-assessment.pdf
  • 4 Salvador FS, Fujita DM. Entry routes for Zika virus in Brazil after 2014 world cup: new possibilities. Travel Med Infect Dis. 2016;14(1):49-51. doi:10.1016/j.tmaid.2015.10.004
  • 5 Kuno G, Chang GJ. Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses. Arch Virol. 2007;152(4):687-96. doi:10.1007/s00705-006-0903-z
  • 6 Marchette NJ, Garcia R, Rudnick A. Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia. Am J Trop Med Hyg. 1969;18(3):411-5.
  • 7 Foy BD, Kobylinski KC, Chilson Foy JL, Blitvich BJ, Travassos da Rosa A, Haddow AD et al. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis. 2011;17(5):880-2. doi:10.3201/eid1705.101939
  • 8 Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau V. Potential sexual transmission of Zika Virus. Emerg Infect Dis. 2015;21(2):359-61. doi:10.3201/eid2102.141363
  • 9 Besnard M, Lastère S, Teissier A, Cao-Lormeau VM, Musso D. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February. Euro Surveill. 2014;19(13):20751. doi:10.2807/1560-7917.ES2014.19.13.20751
  • 10 Musso D, Nhan T, Robin E, Roche C, Bierlaire D, Zisou K et al. Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014. Euro Surveill. 2014;19(14):20771. doi:10.2807/1560-7917.ES2014.19.14.20761
  • 11 Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatel M, Mraz J et al. Zika Virus associated with microcephaly. N Engl J Med. 2016;374(10):951-8. doi:10.1056/NEJMoa1600651
  • 12 Ministério da Saúde (BR), Secretaria de Vigilância em Saúde. [Protocol for surveillance and response to the occurrence of microcephaly related to Zika virus infection]. Brasília, DF: Ministério da Saúde; 2015 [cited 2015 Dec 22]. Available from: http://portalsaude.saude.gov.br/images/pdf/2015/dezembro/09/Microcefalia---Protocolo-de-vigil--ncia-e-resposta---vers--o-1----09dez2015-8h.pdf
  • 13 Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N et al. Biology of Zika Virus infection in human skin cells. J Virol. 2015;89(17):8880-96. doi:10.1128/JVI.00354-15
  • 14 Bell TM, Field EJ, Narang HK. Zika virus infection of the central nervous system of mice. Arch Gesamte Virusforsch. 1971;35(2):183-92. doi:10.1007/BF01249709
  • 15 Kuno G, Chang GJ, Tsuchiya KR, Karabatsos N, Cropp CB. Phylogeny of the genus Flavivirus. J Virol. 1998;72(1):3-83. doi:10.1099/0022-1317-81-9-2339
  • 16 Faye O, Freire CC, Iamarino A, Faye O, Oliveira JV, Diallo M et al. Molecular Evolution of Zika Virus during Its Emergence in the 20(th) Century. PLoS Negl Trop Dis. 2014;8(1):e2636. doi:10.1371/journal.pntd.0002636
  • 17 Zanluca C, Melo VCA, Mosimann ALP, Santos GIV, Santos CND, Luz K. First report of autochthonous transmission of zika virus in Brazil. Mem Inst Oswaldo Cruz. 2015;110(4):569-72. doi:10.1590/0074-02760150192
  • 18 Christo PP. Encephalitis by dengue virus and other arboviruses. Arq Neuropsiquiatr. 2015;73(8):641-3. doi:10.1590/0004-282X20150108
  • 19 Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F et al. Zika virus infection complicated by Guillain-Barré syndrome – case report, French Polynesia, December 2013. Euro Surveill. 2014;19(9):20720. doi:10.2807/1560-7917.ES2014.19.9.20720
  • 20 Wakerley BR, Uncini A, Yuki N, Attarian S, Barreira AA, Chan YC et al. Guillain-Barré and Miller Fisher syndromes: new diagnostic classification. Nat Rev Neurol. 2014;10(9):537-44. doi:10.1038/nrneurol.2014.138