CC BY 4.0 · Aorta (Stamford) 2013; 01(02): 96-101
DOI: 10.12945/j.aorta.2013.13-014
Original Research Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Painless Type B Aortic Dissection

Insights From the International Registry of Acute Aortic Dissection
Jip L. Tolenaar
1   Department of Cardiovascular Surgery, Policlinico San Donato IRCCS, Milan, Italy
,
Stuart J. Hutchison
2   St. Michael's Hospital, Toronto, Ontario, Canada
,
Dan Montgomery
3   University of Michigan Health System, Ann Arbor, Michigan
,
Patrick O'Gara
4   Brigham and Women's Hospital, Boston, Massachusetts
,
Rosella Fattori
5   S. Orsola-Malpighi Hospital, Bologna, Italy
,
Reed E. Pyeritz
6   Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
,
Linda Pape
7   University of Massachusetts Hospital, Worcester, Massachusetts
,
Toru Suzuki
8   Department of Cardiology, University of Tokyo, Tokyo, Japan
,
Arturo Evangelista
9   Hospital General Universitari Vall d'Hebron, Barcelona, Spain
,
Frans L. Moll
10   University Medical Center Utrecht, Utrecht, The Netherlands
,
Vincenzo Rampoldi
1   Department of Cardiovascular Surgery, Policlinico San Donato IRCCS, Milan, Italy
,
Eric M. Isselbacher
11   Massachusetts General Hospital, Boston, Massachusetts
,
Cristoph A. Nienaber
12   Thoracic Aortic Center, University of Rostock, Rostock, Germany
,
Kim A. Eagle
3   University of Michigan Health System, Ann Arbor, Michigan
,
Santi Trimarchi
1   Department of Cardiovascular Surgery, Policlinico San Donato IRCCS, Milan, Italy
› Author Affiliations
Further Information

Publication History

06 March 2013

03 June 2013

Publication Date:
28 September 2018 (online)

Abstract

Introduction: The classical presentation of a patient with Type B acute aortic dissection (TBAAD) is characterized by severe chest, back, or abdominal pain, ripping or tearing in nature. However, some patients present with painless acute aortic dissection, which can lead to a delay in diagnosis and treatment. We utilized the International Registry on Acute Aortic Dissections (IRAD) database to study these patients.

Methods: We analyzed 43 painless TBAAD patients enrolled in the database between January 1996 and July 2012. The differences in presentation, diagnostics, management, and outcome were compared with patients presenting with painful TBAAD.

Results: Among the 1162 TBAAD patients enrolled in IRAD, 43 patients presented with painless TBAAD (3.7%). The mean age of patients with painless TBAAD was significantly higher than normal TBAAD patients (69.2 versus 63.3 years, P = 0.020). The presence of atherosclerosis (46.4% versus 30.1%, P = 0.022), diabetes (17.9% versus 7.5%; P = 0.018), and other aortic diseases (8.6% versus 2.3%, P= 0.051), such as prior aortic aneurysm (31% versus 18.8% P = 0.049) was more common in these patients. Median delay time between presentation and diagnosis was longer in painless patients (median 34.0 versus 19.0 hours; P = 0.006). Dissection of iatrogenic origin (19.5% versus 1.3%; P < 0.001) was significantly more frequent in the painless group. The in-hospital mortality was 18.6% in the painless group, compared with an in-hospital mortality of 9.9% in the control group (P = 0.063).

Conclusion: Painless TBAAD is a relatively rare presentation (3.7%) of aortic dissection, and is often associated with a history of atherosclerosis, diabetes, prior aortic disease including aortic aneurysm, and an iatrogenic origin. We observed a trend for increased in-hospital mortality in painless TBAAD patients, which may be the result of a delay in diagnosis and management. Therefore, physicians should be aware of this relative rare presentation of TBAAD.

 
  • References

  • 1 Imamura H, Sekiguchi Y, Iwashita T, Dohgomori H, Mochizuki K, Aizawa K. , et al. Painless acute aortic dissection. Diagnostic, prognostic and clinical implications. Circ J 2011; 75: 59-66 . 10.1253/circj.CJ-10-0183
  • 2 Park SW, Hutchison S, Mehta RH, Isselbacher EM, Cooper JV, Fang J. , et al. Association of painless acute aortic dissection with increased mortality. Mayo Clin Proc 2004; 79: 1252-1257 . 10.4065/79.10.1252
  • 3 Lindsay Jr J. Aortic dissection. Heart Dis Stroke 1992; 1: 69-76
  • 4 Mészáros I, Mórocz J, Szlávi J, Schmidt J, Tornóci L, Nagy L. , et al. Epidemiology and clinicopathology of aortic dissection. Chest 2000; 117: 1271-1278 . 10.1378/chest.117.5.1271
  • 5 Hagan PG, Nienaber CA, Isselbacher EM, Bruckman D, Karavite DJ, Russman PL. , et al. The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease. JAMA 2000; 283: 897-903 . 10.1001/jama.283.7.897
  • 6 Hirata K, Wake M, Kyushima M, Takahashi T, Nakazato J, Mototake H. , et al. Electrocardiographic changes in patients with type A acute aortic dissection. Incidence, patterns and underlying mechanisms in 159 cases. J Cardiol 2010; 56: 147-153 . 10.1016/j.jjcc.2010.03.007
  • 7 Nallamothu BK, Mehta RH, Saint S, Llovet A, Bossone E, Cooper JV. , et al. Syncope in acute aortic dissection: diagnostic, prognostic, and clinical implications. Am J Med 2002; 113: 468-471 . 10.1016/S0002-9343(02)01254-8
  • 8 Blakeman BM, Pifarre R, Sullivan HJ, Montoya A, Bakhos M, Grieco JG. , et al. Perioperative dissection of the ascending aorta: types of repair. J Card Surg 1988; 3: 9-14 . 10.1111/j.1540-8191.1988.tb00212.x
  • 9 Pérez-Castellano N, García-Fernández MA, García EJ, Delcán JL. Dissection of the aortic sinus of Valsalva complicating coronary catheterization: cause, mechanism, evolution, and management. Cathet Cardiovasc Diagn 1998; 43: 273-279 . 10.1002/(SICI)1097-0304(199803)43:3<273::AID-CCD7>3.0.CO;2-6
  • 10 Still RJ, Hilgenberg AD, Akins CW, Daggett WM, Buckley MJ. Intraoperative aortic dissection. Ann Thorac Surg 1992; 53: 374-380 . 10.1016/0003-4975(92)90254-2
  • 11 Yip HK, Wu CJ, Yeh KH, Hang CL, Fang CY, Hsieh KY. , et al. Unusual complication of retrograde dissection to the coronary sinus of valsalva during percutaneous revascularization: a single-center experience and literature review. Chest 2001; 119: 493-501 . 10.1378/chest.119.2.493
  • 12 Trimarchi S, Tsai T, Eagle KA, Isselbacher EM, Froehlich J, Cooper JV. , et al. Acute abdominal aortic dissection: insight from the International Registry of Acute Aortic Dissection (IRAD). J Vasc Surg 2007; 46: 913-919 . 10.1016/j.jvs.2007.07.030
  • 13 Trimarchi S, Tolenaar JL, Tsai TT, Froehlich J, Pegorer M, Upchurch GR. , et al. Influence of clinical presentation on the outcome of acute B aortic dissection: evidences from IRAD. J Cardiovasc Surg 2012; 53: 161-168 . 10.3410/f.716447806.791852805