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Thromb Haemost 2016; 116(S 01): S2-S9
DOI: 10.1160/TH16-01-0048
5th International Coagulation Meeting 2015 – Barcelona, Spain
Schattauer GmbH

Key insights to understand the immunogenicity of FVIII products

Jenny Goudemand
1   School of Medicine, University of Lille, Lille, France
,
Flora Peyvandi
2   Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico and University of Milan, Italy
,
Sébastien Lacroix-Desmazes
3   INSERM UMR S 1138, Centre de Recherche des Cordeliers, Paris, France
› Author Affiliations
Further Information

Publication History

Received: 20 January 2016

Accepted after major revision: 04 July 2016

Publication Date:
15 December 2017 (online)

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Summary

The treatment of haemophilia has made significant progress in recent decades, and patients are now being treated safely with great clotting products. However, inhibitor development remains the largest problem, particularly in children. Consequently, the haemostasis that was obtained with traditional clotting factors is not being achieved. Moreover, inhibitor complications translate into adult life and there are an increasing number of situations where adult patients with an inhibitor require major surgery but the clinician is faced with the knowledge that required haemostasis levels are difficult to achieve. Therefore, it is of upmost importance to consider factors relating to inhibitor development, and to determine how inhibitors can be prevented and/or eliminated. Of the various factors at play with regard to inhibitor development, it is important to consider the immunogenicity of factor VIII (FVIII) products, and this topic is the focus of the current paper.

Keywords

Haemophilia - FVIII concentrates - immunogenicity - inhibitor - von Willebrand factor
 

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