Procoagulants for management of bleeding with the new oral anticoagulants

Insight on: Perzborn et al. Thromb Haemost 2013; 110: 162-172.

• References

• 1 Perzborn E, Gruber A, Tinel H. et al. Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates. Thromb Haemost 2013; 110: 162-172.
• 2 Eerenberg ES, Kamphuisen PW, Sijpkens MK. et al. Reversal of rivaroxaban and dabigatran by pro thrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 2011; 124: 1573-1579.
• 3 Godier A, Miclot A, Le Bonniec B, Durand M. et al. Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model. Anesthesiology 2012; 116: 94-102.
• 4 Zhou W, Zorn M, Nawroth P. et al. Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban. Stroke 2013; 44: 771-778.
• 5 Southworth MR, Reichman ME, Unger EF. Dabi gatran and postmarketing reports of bleeding. N Engl J Med 2013; 368: 1272-1274.
• 6 Weitz JI, Quinlan DJ, Eikelboom JW. Peripro cedural management and approach to bleeding in patients taking dabigatran. Circulation 2012; 126: 2428-2432.