Thromb Haemost 2013; 109(01): 7
DOI: 10.1160/TH12-11-0805
T&H Insight
Schattauer GmbH

Isoform-specific effects of protein phosphatase 1 on outside-in signalling of integrin αIIbβ3: A story told by genetic manipulation of platelet surrogate cells

Karlheinz Peter
1   Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia
› Author Affiliations
Further Information

Publication History

Received: 08 November 2012

Accepted: 08 November 2012

Publication Date:
15 December 2017 (online)

Insight to: Alrehani et al. Thromb Haemost 2013; 109: 118-126.

 
  • References

  • 1 Alrehani N, Pradhan S, Khatlani T. et al. Distinct roles of the α, β, γ1 isoforms of protein phosphatase 1 in outside-in αIIbβ3 integrin signaling dependent functions. Thromb Haemost 2013; 109: 118-126.
  • 2 Ylänne J, Chen Y, O’Toole TE. et al. Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions. J Cell Biol 1993; 122: 223-233. DOI:10.1083/jcb.122.1.223.
  • 3 O’Toole TE, Katagiri Y, Faull RJ. et al. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol 1994; 124: 1047-1059. DOI:10.1083/jcb.124.6.1047.
  • 4 Ungerer M, Peluso M, Gillitzer A. et al. Generation of functional culture-derived platelets from CD34+ progenitor cells to study transgenes in the platelet environment. Circ Res 2004; 95: e36-44. DOI:10.1161/01.RES.0000141700.96085.2e.
  • 5 Gong H, Shen B, Flevaris P. et al. G protein subunit Gα13 binds to integrin αIIbβ3 and mediates integrin “outside-in” signalling. Science 2010; 327: 340-343. DOI:10.1126/science.1174779.
  • 6 Thijs T, Deckmyn H, Broos K. Model systems of genetically modified platelets. Blood 2012; 119: 1634-1642. DOI:10.1182/blood-2011-10-381715.
  • 7 Armstrong PC, Peter K. GPIIb/IIIa inhibitors: from bench to bedside and back to bench again. Thromb Haemost 2012; 107: 808-814. DOI:10.1160/TH11-10-0727.