Thromb Haemost 2013; 110(02): 386-389
DOI: 10.1160/TH12-09-0701
Letters to the Editor
Schattauer GmbH

Increased platelet Ca2+ channel Orai1 expression upon platelet activation and in patients with acute myocardial infarction

Alexander Tolios*
1   Department of Cardiology and Cardiovascular Medicine, University of Tübingen, Germany
2   Department of Physiology, University of Tübingen, Germany
,
Sergios Gatidis*
2   Department of Physiology, University of Tübingen, Germany
,
Patrick Münzer
2   Department of Physiology, University of Tübingen, Germany
,
Guoxing Liu
2   Department of Physiology, University of Tübingen, Germany
,
Syeda T. Towhid
2   Department of Physiology, University of Tübingen, Germany
,
Athanasios Karathanos
1   Department of Cardiology and Cardiovascular Medicine, University of Tübingen, Germany
,
Elli Tavlaki
1   Department of Cardiology and Cardiovascular Medicine, University of Tübingen, Germany
,
Tobias Geisler
1   Department of Cardiology and Cardiovascular Medicine, University of Tübingen, Germany
,
Peter Seizer
1   Department of Cardiology and Cardiovascular Medicine, University of Tübingen, Germany
,
Andreas E. May
1   Department of Cardiology and Cardiovascular Medicine, University of Tübingen, Germany
,
Boris Bigalke
1   Department of Cardiology and Cardiovascular Medicine, University of Tübingen, Germany
3   King’s College London, St Thomas Hospital, The Rayne Institute, Centre of Excellence, Division of Imaging Science and Biomedical Engineering, London, UK
,
Oliver Borst
1   Department of Cardiology and Cardiovascular Medicine, University of Tübingen, Germany
2   Department of Physiology, University of Tübingen, Germany
,
Meinrad Gawaz
1   Department of Cardiology and Cardiovascular Medicine, University of Tübingen, Germany
,
Florian Lang
2   Department of Physiology, University of Tübingen, Germany
› Author Affiliations
Further Information

Publication History

Received: 27 September 2012

Accepted after major revision: 05 May 2013

Publication Date:
04 December 2017 (online)

 

* Both authors contributed equally.


 
  • References

  • 1 Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002; 08: 1227-1234.
  • 2 Borst O, Munzer P, Gatidis S. et al. The inflammatory chemokine CXC motif ligand 16 triggers platelet activation and adhesion via CXC motif receptor 6-dependent phosphatidylinositide 3-kinase/ Akt signaling. Circ Res 2012; 111: 1297-1307.
  • 3 Gawaz M, Reininger A, Neumann FJ. Platelet function and platelet-leukocyte adhesion in symptomatic coronary heart disease. Effects of intravenous magnesium. Thromb Res 1996; 83: 341-349.
  • 4 Stellos K, Bigalke B, Langer H. et al. Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells. Eur Heart J 2009; 30: 584-593.
  • 5 Bigalke B, Stellos K, Geisler T. et al. Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke. European Journal of Neurology 2010; 17: 111-117.
  • 6 Bergmeier W, Stefanini L. Novel molecules in calcium signaling in platelets. J Thromb Haemost 2009; 7 Suppl 1: 187-190.
  • 7 Borst O, Schmidt EM, Munzer P. et al. The serumand glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. Blood 2012; 119: 251-261.
  • 8 Bergmeier W, Oh-hora M, McCarl CA. et al. R93W mutation in Orai1 causes impaired calcium influx in platelets. Blood 2009; 113: 675-678.
  • 9 Braun A, Varga-Szabo D, Kleinschnitz C. et al. Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation. Blood 2009; 113: 2056-2063.
  • 10 Massberg S, Gawaz M, Gruner S. et al. A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med 2003; 197: 41-49.
  • 11 Bisaillon JM, Motiani RK, Gonzalez-Cobos JC. et al. Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration. Am J Physiol Cell Physiol 2010; 298: C993-1005.
  • 12 Bigalke B, Lindemann S, Ehlers R. et al. Expression of platelet collagen receptor glycoprotein VI is associated with acute coronary syndrome. Eur Heart J 2006; 27: 2165-2169.
  • 13 Bigalke B, Stellos K, Stakos D. et al. Influence of platelet count on the expression of platelet collagen receptor glycoprotein VI (GPVI) in patients with acute coronary syndrome. Thromb Haemost 2009; 101: 911-915.
  • 14 Seizer P, Stellos K, Selhorst G. et al. CXCL16 is a novel scavenger receptor on platelets and is associated with acute coronary syndrome. Thromb Haemost 2011; 105: 1112-1114.
  • 15 Body R, Pemberton P, Ali F. et al. Low soluble P-selectin may facilitate early exclusion of acute myocardial infarction. Clin Chim Acta 2011; 412: 614-618.
  • 16 Jackson SP, Schoenwaelder SM, Goncalves I. et al. PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med 2005; 11: 507-514.
  • 17 Yin H, Stojanovic A, Hay N. et al. The role of Akt in the signaling pathway of the, glycoprotein Ib- IX-induced platelet activation. Blood 2008; 111: 658-665.
  • 18 Konopatskaya O, Gilio K, Harper MT. et al. PKCalpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest 2009; 119: 399-407.
  • 19 Woodard GE, Salido GM, Rosado JA. Enhanced exocytotic-like insertion of Orai1 into the plasma membrane upon intracellular Ca2+ store depletion. Am J Physiol Cell Physiol 2008; 294: C1323-C1331.
  • 20 Zbidi H, Lopez JJ, Amor NB. et al. Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus. Blood Cells Mol Dis 2009; 43: 211-213.
  • 21 Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005; 115: 3378-3384.