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Thromb Haemost 2010; 104(03): 432-439
DOI: 10.1160/TH09-11-0771
Theme Issue Article
Schattauer GmbH

Tissue factor and thrombosis: The clot starts here

A. Phillip Owens III
1   Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
,
Nigel Mackman
1   Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
› Author Affiliations
Further Information

Publication History

Received: 13 November 2009

Accepted after minor revision: 29 March 2010

Publication Date:
23 November 2017 (online)

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Summary

Thrombosis, or complications from thrombosis, currently occupies the top three positions in the cardiovascular causes of morbidity and mortality in the developed world. There are a limited number of safe and effective drugs to prevent and treat thrombosis. Animal models of thrombosis are necessary to better understand the complex components and interactions involved in the formation of a clot. Tissue factor (TF) is required for the initiation of blood coagulation and likely plays a key role in both arterial and venous thrombosis. Understanding the role of TF in thrombosis may permit the development of new antithrombotic drugs. This review will focus on the role of TF in in vivo models of thrombosis.

Keywords

Tissue factor / factor VII - thrombosis - arterial thrombosis - venous thrombosis - animal models
 

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