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Thromb Haemost 2010; 103(03): 586-595
DOI: 10.1160/TH09-10-0716
Theme Issue Article
Schattauer GmbH

Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics

Richard Becker
1   Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina, USA
,
Thomas Povsic
2   Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
,
Mauricio G. Cohen
3   Miller School of Medicine, University of Miami, Miami, Florida, USA
4   Cardiac Catheterization Laboratory, University of Miami Hospital, Miami, Florida, USA
,
Christopher Rusconi
5   Regado Biosciences, Inc, Durham, North Carolina, USA
,
Bruce Sullenger
6   Department of Genetics, Center for Genetics and Cellular Therapies, Duke University Medical Center, Durham, North Carolina, USA
› Author Affiliations
Further Information

Publication History

Received: 21 October 2009

Accepted after minor revision: 17 February 2009

Publication Date:
22 November 2017 (online)

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Summary

Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.

Keywords

Nucleic acids - RNA and DNA aptamers - protein-binding oligonucleotides - anticoagulant therapy
 

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