Thromb Haemost 2010; 103(02): 475-477
DOI: 10.1160/TH09-09-0571
Letters to the Editor
Schattauer GmbH

A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections

Mary K. Boudreaux
1   Department of Pathobiology, Auburn University, Auburn, Alabama, USA
,
Jane K. Wardrop
2   Department of Veterinary Clinical Sciences, Washington State University, Pullman, Washington, USA
,
Veronika Kiklevich
3   San Antonio Veterinary Referral Specialists, San Antonio, Texas, USA
,
Peter Felsburg
4   Department of Clinical Studies-PHL, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Kevin Snekvik
5   Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received: 17. August 2009

Accepted after major revision: 15. Oktober 2009

Publikationsdatum:
22. November 2017 (online)

 

 
  • References

  • 1 Pasvolsky R, Feigelson SW, Kilic SS. et al. A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets. J Exp Med 2007; 204: 1571-1582.
  • 2 Kilic SS, Etzioni A. The clinical spectrum of Leukocyte Adhesion Deficiency (LAD) III due to defective CalDAG-GEFI. J Clin Immunol 2009; 29: 117-122.
  • 3 Crittenden JR, Bergmeier W, Zhang Y. et al. CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nature Medicine 2004; 10: 982-986.
  • 4 Bergmeier W, Goerge T, Wang HW. et al. Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. J Clin Invest 2007; 117: 1699-1707.
  • 5 Boudreaux MK, Catalfamo JL, Klok M. Calcium-diacylglycerol guanine nucleotide exchange factor I gene mutations associated with loss of function in canine platelets. Translational Res 2007; 150: 81-92.
  • 6 Boudreaux MK, Schmutz S, French P. Calcium diacylglycerol guanine nucleotide exchange factor I (CalDAG-GEFI) gene mutations in a thrombopathic Simmental calf. Vet Pathol 2007; 44: 932-945.
  • 7 Kuijpers TW, van de Vijver E, Weterman MAJ. et al. LAD1/variant syndrome is caused by mutations in FERMT3. Blood 2009; 113: 4740-4746.
  • 8 Svensson L, Howarth K, McDowall A. et al. Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nature Med 2009; 15: 306-312.
  • 9 Malinin NL, Zhang L, Choi J. et al. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nature Medicine 2009; 15: 313-318.
  • 10 Moser M, Nieswandt B, Ussar S. et al. Kindlin-3 is essential for integrin activation and platelet aggregation. Nature Medicine 2008; 14: 325-330.
  • 11 Moser M, Bauer M, Schmid S. et al. Kindlin-3 is required for β2 integrin-mediated leukocyte adhesion to endothelial cells. Nature Med 2009; 15: 300-305.