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Thromb Haemost 2010; 103(03): 630-637
DOI: 10.1160/TH09-07-0453
Platelets and Blood Cells
Schattauer GmbH

Polymorphisms in platelet glycoproteins Ia and IIIa are associated with arterial thrombosis and carotid atherosclerosis in type 2 diabetes

Silvia Pellitero
1   Endocrinology and Nutrition Service, Department of Internal Medicine (Universitat Autònoma de Barcelona) Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain
,
Jordi L. Reverter
1   Endocrinology and Nutrition Service, Department of Internal Medicine (Universitat Autònoma de Barcelona) Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain
,
Dolors Tàssies
2   Hemotherapy and Haemostasis Service, IDIBAPS, Hospital Clinic, Barcelona, Spain
,
Eduarda Pizarro
3   Endocrinology Unit, Mataró Hospital, Spain
,
Juan Monteagudo
2   Hemotherapy and Haemostasis Service, IDIBAPS, Hospital Clinic, Barcelona, Spain
,
Isabel Salinas
1   Endocrinology and Nutrition Service, Department of Internal Medicine (Universitat Autònoma de Barcelona) Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain
,
Eva Aguilera
1   Endocrinology and Nutrition Service, Department of Internal Medicine (Universitat Autònoma de Barcelona) Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain
,
Anna Sanmartí
1   Endocrinology and Nutrition Service, Department of Internal Medicine (Universitat Autònoma de Barcelona) Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain
,
Juan Carlos Reverter
2   Hemotherapy and Haemostasis Service, IDIBAPS, Hospital Clinic, Barcelona, Spain
› Author Affiliations Financial support:This study was supported by a grant “Ajut a la recerca en diabetis Gonçal Lloveras i Vallès” from the Catalan Association of Diabetes and by grants FIS PI050204 and PI070387 from the Spanish Ministry of Health. DT and JCR are members of a Spanish cardiovascular research network (Red HERACLES RD06/009/1033) funded by the Ministry of Health, Instituto de Salud Carlos III.
Further Information

Publication History

Received: 14 July 2009

Accepted after major revision: 06 January 2009

Publication Date:
22 November 2017 (online)

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Summary

To determine the genotype distributions of the polymorphisms in platelet glycoproteins (GP) Ib-alpha, Ia/IIa and IIb/IIIa and their association with clinical arterial thrombosis and preclinical carotid atherosclerosis in type 2 diabetes we studied 229 patients with type 2 diabetes and 229 controls matched by age, gender and ethnicity. Biochemical and haemostasis analyses were performed. The GP Ib-alpha VNTR, GP Ia 807 C/T and GP IIIa Pl(A) polymorphisms were determined by PCR. Thrombotic events were registered and carotid atherosclerosis was evaluated by ultrasound examination. A total of 107 patients had clinical atherothrombosis (CA), 65 subclinical atherosclerosis (SA), and 57 had no evidence of atherosclerosis (NA). There were no differences in allele frequencies and the genotype distribution of platelet GP polymorphisms between diabetic patients and controls. The VNTR Ib-alpha polymorphism was not associated with CA. We found a significant association between CA and the 807T (odds ratio [OR]: 2.86, confidence interval [CI]: 1.65–4.93; p<0.001) and PlA2 (OR: 2.03, CI: 1.13–3.65; p=0.03) alleles (in GP Ia and GP IIIa, respectively) in comparison to SA and NA group. Diabetic patients with the coexistence of the 807T and PlA2 alleles presented the highest risk of CA (OR: 3.59, CI: 1.64–7.8; p<0.001). The coexistence of both 807T and PlA2 alleles was also associated with the presence of SA (OR: 9.00, CI: 1.10–73.42; p=0.04). In conclusion, the 807T allele of GP Ia and the PlA2 allele of GP IIIa, and specially its combination, may confer an additional risk for development of carotid atherosclerosis and arterial thrombosis in type 2 diabetes.

Keywords

Arterial thrombosis - carotid atherosclerosis - platelet glycoprotein - polymorphism - type 2 diabetes
 

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