Thromb Haemost 2009; 102(02): 183-184
DOI: 10.1160/TH09-06-0350
Editorial Focus
Schattauer GmbH

Genetic variants and risk for venous thromboembolic events: Summing up the evidence

Daniel Kurnik
1   Division of Clinical Pharmacology and Toxicology, and Department of Medicine A, Chaim Sheba Medical Center, Tel Hashomer, Israel
3   Sackler Faculty of Medicine, Tel Aviv University, Israel
,
Aaron Lubetsky
2   National Hemophilia Center and Institute of Thrombosis and Hemostasis, Department of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Israel
3   Sackler Faculty of Medicine, Tel Aviv University, Israel
› Author Affiliations
Further Information

Publication History

Received: 05 June 2009

Accepted: 05 June 2009

Publication Date:
22 November 2017 (online)

 

 
  • References

  • 1 Jordan FL, Nandorff A. The familial tendency in thrombo-embolic disease. Acta Med Scand 1956; 156: 267-275.
  • 2 Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Thromb Diath Haemorrh 1965; 13: 516-530.
  • 3 Gohil R, Peck G, Sharma P. The genetics of venous thromboembolism: a meta-analysis involving ∼120,000 cases and 180,000 controls. Thromb Haemost 2009; 102: 360-370.
  • 4 Stroup DF, Berlin JA, Morton SC. et al. Metaanalysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. J Am Med Assoc 2000; 283: 2008-2012.
  • 5 Vossen CY, Conard J, Fontcuberta J. et al. Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). J Thromb Haemost 2005; 03: 459-464.
  • 6 Couturaud F, Kearon C, Leroyer C. et al. Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. Thromb Haemost 2006; 96: 744-749.
  • 7 Simioni P, Tormene D, Prandoni P. et al. Incidence of venous thromboembolism in asymptomatic family members who are carriers of factor V Leiden: a prospective cohort study. Blood 2002; 99: 1938-1942.
  • 8 Middeldorp S, Meinardi JR, Koopman MM. et al. A prospective study of asymptomatic carriers of the factor V Leiden mutation to determine the incidence of venous thromboembolism. Ann Intern Med 2001; 135: 322-327.
  • 9 Cushman M, Tsai AW, White RH. et al. Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. Am J Med 2004; 117: 19-25.
  • 10 Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med 2001; 344: 1222-1231.
  • 11 Juul K, Tybjaerg-Hansen A, Schnohr P. et al. Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Ann Intern Med 2004; 140: 330-337.
  • 12 Vossen CY, Conard J, Fontcuberta J. et al. Familial thrombophilia and lifetime risk of venous thrombosis. J Thromb Haemost 2004; 02: 1526-1532.
  • 13 Bezemer ID, van der Meer FJ, Eikenboom JC. et al. The value of family history as a risk indicator for venous thrombosis. Arch Intern Med 2009; 169: 610-615.