Thromb Haemost 2009; 102(03): 606-608
DOI: 10.1160/TH09-02-0114
Letters to the Editor
Schattauer GmbH

PPACK-Desmodus rotundus salivary plasminogen activator (cDSPAα1) prevents the passage of tissuetype plasminogen activator (rt-PA) across the blood-brain barrier and neurotoxicity

Benoit D. Roussel*
1   INSERM, INSERM U919, Serine Proteases and Pathophysiology of the neurovascular Unit, CNRS, UMR CNRS 6232 CINAPs “Center for Imaging Neurosciences and Applications to Pathologies”, Cyceron, Caen Cedex, F-14074 France; University of Caen Basse-Normandie, Caen Cedex, France
,
Yannick Hommet*
1   INSERM, INSERM U919, Serine Proteases and Pathophysiology of the neurovascular Unit, CNRS, UMR CNRS 6232 CINAPs “Center for Imaging Neurosciences and Applications to Pathologies”, Cyceron, Caen Cedex, F-14074 France; University of Caen Basse-Normandie, Caen Cedex, France
,
Richard Macrez
1   INSERM, INSERM U919, Serine Proteases and Pathophysiology of the neurovascular Unit, CNRS, UMR CNRS 6232 CINAPs “Center for Imaging Neurosciences and Applications to Pathologies”, Cyceron, Caen Cedex, F-14074 France; University of Caen Basse-Normandie, Caen Cedex, France
,
Torsten Schulz
2   PAION Deutschland GmbH, Aachen, Germany
,
Karl-Uwe Petersen
2   PAION Deutschland GmbH, Aachen, Germany
,
Vincent Berezowski
3   Laboratoire de Physiopathologie de la Barrière Hémato-Encéphalique, EA 2465, IFR114-IMPRT, Université d’Artois, Faculté des Sciences Jean Perrin, France
,
Roméo Cecchelli
3   Laboratoire de Physiopathologie de la Barrière Hémato-Encéphalique, EA 2465, IFR114-IMPRT, Université d’Artois, Faculté des Sciences Jean Perrin, France
,
Carine Ali
1   INSERM, INSERM U919, Serine Proteases and Pathophysiology of the neurovascular Unit, CNRS, UMR CNRS 6232 CINAPs “Center for Imaging Neurosciences and Applications to Pathologies”, Cyceron, Caen Cedex, F-14074 France; University of Caen Basse-Normandie, Caen Cedex, France
,
Denis Vivien
1   INSERM, INSERM U919, Serine Proteases and Pathophysiology of the neurovascular Unit, CNRS, UMR CNRS 6232 CINAPs “Center for Imaging Neurosciences and Applications to Pathologies”, Cyceron, Caen Cedex, F-14074 France; University of Caen Basse-Normandie, Caen Cedex, France
› Author Affiliations
Financial support: This study was supported in part by research funding from PAION Deutschland GmbH.
Further Information

Publication History

Received: 23 February 2009

Accepted after major revision: 23 June 2009

Publication Date:
22 November 2017 (online)

 

* These authors contributed equally to this work.


 
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