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Thromb Haemost 2006; 96(01): 14-18
DOI: 10.1160/TH06-02-0086
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Factor V Leiden mutation and pregnancy-related venous thromboembolism: What is the exact risk?

Results from a meta-analysis
Christine Biron-Andreani
1   Hopital Saint-Eloi, Laboratoire d’ Hematologie, Montpellier, France
,
Jean-Francois Schved
1   Hopital Saint-Eloi, Laboratoire d’ Hematologie, Montpellier, France
,
Jean-Pierre Daures
2   IURC, Laboratoire de Recherche en Biostatistiques et Epidemiologie, Montpellier, France
› Author Affiliations
Further Information

Publication History

Received 13 February 2006

Accepted after resubmission 24 May 2006

Publication Date:
29 November 2017 (online)

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Summary

The magnitude of the association of factor V Leiden mutation with pregnancy-related venous thrombosis remains unclear. Our objective was to undertake a systematic review and a meta-analysis of the literature to estimate precisely the association of factor V Leiden mutation with the risk of first,or recurrent,pregnancy-related venous thromboembolism. Studies published before October 2005 were identified by Medline®. Using both fixed and random effect models, odds ratios (OR) with accompanying 95% confidential intervals (CI) were calculated for the factor V Leiden mutation and the clinical end-point (Yusuf-Peto adaptation of the Mantel-Haenszel, DerSimonian and Laird method).We identified 13 studies including 7 cohorts and 6 case control studies relating to factor V Leiden and pregnancy-related venous thrombosis.The results from the cohorts showe a pooled OR of 4.46 (95% CI,1.82–10.94;7,879 pooled women), with no evidence of statistical heterogeneity (p=0.36), for the risk of a first venous thromboembolism during pregnancy or the postpartum period associated with the factor V Leiden mutation.Case-control studies revealed a higher risk ( OR 8.6,95% CI, 5.85–12.63; 1,524 pooled women) with significant heterogeneity (p<0.005). Because of insufficient data, an analysis for the risk of recurrence could not be performed. Our findings emphasize the fact that limited data are available on this topic.This meta-analysis provides clinicians with an estimate of the average risk of a first thrombosis occurring during pregnancy in women carrying the factor V Leiden to assist the management of such women.

Keywords

FactorV Leiden mutation - venous thrombosis - pregnancy - meta-analysis
 

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