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Thromb Haemost 2006; 96(01): 24-28
DOI: 10.1160/TH06-01-0027
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Interleukin-10 promoter polymorphism and venous thrombosis

A case-control study
Eva Cochery-Nouvellon
1   Laboratoire Central d’hématologie
3   Unité UPRES EA3796 IFR53, Faculté de Médecine et de Pharmacie, Université de Reims Champagne-Ardenne, France
,
Fabien Vitry
2   Unité d’aide méthodologique, CHU Robert Debré
,
Pascale Cornillet-Lefebvre
1   Laboratoire Central d’hématologie
3   Unité UPRES EA3796 IFR53, Faculté de Médecine et de Pharmacie, Université de Reims Champagne-Ardenne, France
,
Nathalie Hezard
1   Laboratoire Central d’hématologie
,
Lucile Gillot
1   Laboratoire Central d’hématologie
,
Philippe Nguyen
1   Laboratoire Central d’hématologie
3   Unité UPRES EA3796 IFR53, Faculté de Médecine et de Pharmacie, Université de Reims Champagne-Ardenne, France
› Author Affiliations
Further Information

Publication History

Received 17 January 2006

Accepted after resubmission 14 May 2006

Publication Date:
29 November 2017 (online)

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Summary

The human interleukin-10 promoter gene is highly polymorphic. IL-10 polymorphisms have been associated with various autoimmune and lymphoproliferative disorders. Although IL-10 has been shown to modulate thrombin generation in several experimental models, it is not known whether IL-10 polymorphisms could be a risk factor for venous thrombosis. We therefore conducted a case-control study comparing 74 consecutive patients who experienced at least one episode of documented venous thromboembolic event and 100 healthy controls. All subjects were Caucasians. Five polymorphisms of the IL-10 promoter gene were studied: two highly polymorphic dinucleotide repeats, IL-10 R and IL-10G, and three single nucleotide polymorphisms at position −1082, −819 and −592. Factor VG1691C Leiden mutation was systematically determined. Multivariate logistic regression analysis showed that IL-10 G13 and G10 alleles are independent risk factors for venous thrombosis (Odds ratio:OR = 3.33, p = 0.003 and OR = 2.83, p = 0.03, respectively). Furthermore, IL-10 G10 allele is more frequent in recurrent disease.

Keywords

Deep vein thrombosis - interleukin-10 - factor V Leiden - hereditary thrombosis risk factor
 

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