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DOI: 10.1160/TH04-05-0289
Development of DX-9065a, a novel direct factor Xa antagonist, in cardiovascular disease
Publication History
Received
10 May 2004
Accepted after revision
04 October 2004
Publication Date:
02 December 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/200406/lookinside/thumbnails/10-1160-th04-05-0289-1.jpg)
Summary
The development of anticoagulants for treating patients with atherothrombotic disorders of the arterial circulatory system has focused, either directly or indirectly, on thrombin – a pleuripotential effector enzyme with prothrombotic and proinflammatory properties. The pivotal role of factor (f) Xa in thrombin generation, coupled with its direct cellular effects and widely recognized limitations of currently available anticoagulants, has led to the development of pharmacologic inhibitors of this important protease. The following review focuses on DX9065a – first in a class of direct, selective and reversible fXa antagonists – and its potential applications in the management of patients with cardiovascular disease.
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