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Thromb Haemost 2004; 91(05): 1031-1034
DOI: 10.1160/TH03-11-0690
Cell Signaling and Vessel Remodeling
Schattauer GmbH

Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke

Justo Aznar
1   Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Yolanda Mira
1   Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Amparo Vayá
1   Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Dolores Corella
2   Molecular Epidemiology Unit, School of Medicine University of Valencia, Spain
,
Fernando Ferrando
1   Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Piedad Villa
1   Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Amparo Estellés
3   Research Center, La Fe University Hospital, Valencia, Spain
› Author Affiliations
Further Information

Publication History

Received 13 November 2003

Accepted after resubmission 16 February 2004

Publication Date:
01 December 2017 (online)

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Summary

The association between factor V Leiden (FVL) and prothrombin G20210A (PT 20210) mutations and ischemic stroke remains controversial, particularly in young adults with cryptogenic stroke. Prevalence of FVL (4.1%) and PT 20210 (8.2%) mutations was assessed in 49 patients under 50 years with cryptogenic stroke and compared with controls. Odd ratio (OR) for cryptogenic stroke was 2.62 (95% CI, 0.49-13.95) for FVL and 3.75 (95% CI, 1.05-13.34) for PT 20210 and 3.28 (95% CI, 1,17-9.20) for some recognized genetic thrombophilic defect. Moreover, the OR for cryptogenic stroke in young women using oral contraceptives (OC) was 3.59 (95% CI, 1.28-10.5). When some genetic thrombophilic defect was associated with OC, the OR was much higher (OR: 14.27; 95% CI, 0.66-309.99). Our results suggest that in the Mediterranean populations the PT 20210 mutation, but not FV Leiden, is a risk factor for cryptogenic stroke in young adults. OC use is also a significant risk factor for cryptogenic stroke, which is increased in women with some genetic thrombotic risk factor.

Keywords

Stroke - factor V Leiden - prothrombin G20210A mutation - cryptogenic stroke - oral contraceptives
 

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