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Thromb Haemost 2004; 91(02): 360-366
DOI: 10.1160/TH03-04-0256
Platelets and Blood Cells
Schattauer GmbH

Relationships between plasma adiponectin and blood cells, hepatopancreatic enzymes in women

Miyao Matsubara
1   Division of Endocrinology and Metabolism, Otaru City General Hospital, Otaru, Japan
,
Katsuhiko Namioka
2   Laboratory Medicine, Otaru City General Hospital, Otaru, Japan
,
Shinji Katayose
3   Otsuka Assay Institute, Sapporo, Japan
› Author AffiliationsGrant support: This work was supported in part by a grant from the Tanita Health Body Weight Foundation in Japan.
Further Information

Publication History

Received 30 April 2003

Accepted after resubmission 11 January 2003

Publication Date:
01 December 2017 (online)

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Summary

Adiponectin, which is secreted specifically from adipocyte, is thought to play a key role in the metabolic syndrome. We studied the associations of plasma adiponectin concentrations with blood cells and hepatopancreatic enzymes in 339 women aged 54.0 ± 0.8 (mean ± SE) years. Plasma adiponectin before and after adjustment for body composition or calculated insulin resistance increased in slight anemic women (372.6 ± 2.6 ×104/mm3) compared with non-anemic subjects (471.1 ± 1.7) (all p < 0.0001), and were inversely associated with red blood cells (RBC), hemoglobin, hematocrit, white blood cells and platelet values (p < 0.0001 ∼ 0.02), independent of age, diastolic blood pressure, body mass index, serum triglyceride, insulin resistance or blood urea nitrogen. Age and adiponectin/body fat mass (%) were negative, and blood pressure and insulin resistance were positive significant independent determinants of RBC in stepwise regression analysis. Moreover, adiponectin before and after adjustment were inversely associated with serum ALAT,γGTP and ChE, and positively with amylase levels (p < 0.0001 ∼ 0.02). These results indicate the possibility that increased adiponectin may contribute to the suppressive bone marrow function in vivo. Combined with the leptin’s data, adipocyte derived proteins were related to the hematopoiesis, therefore it has shown the possible existence of adipose tissue/ bone marrow function linkage more clearly. Furthermore, hepatopancreatic enzyme associations with this protein may indicate the possibility that adiponectin will regulate the hepatopancreatic function in health and disease.

Keywords

Adiponectin - hematopoiesis - blood cell - hepatic enzyme - amylase
 

  • References

  • 1 Maeda K, Okubo K, Shimomura I. et al. cDNA cloning and expression of a novel adipose specific collagen-like factor, apMI (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 1996; 221: 286-9.
    CrossrefPubMedGoogle Scholar
  • 2 Ouchi N, Kihara S, Arita Y. et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 1999; 100: 2473-6.
    CrossrefPubMedGoogle Scholar
  • 3 Okamoto Y, Arita Y, Nishida M. et al. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res 2000; 32: 47-50.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Yokota T, Oritani K, Takahashi I. et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 2000; 96: 1723-32.
    PubMedGoogle Scholar
  • 5 Ouchi N, Kihara S, Arita Y. et al. Adipocytederived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocytederived macrophages. Circulation 2001; 103: 1057-63.
    CrossrefPubMedGoogle Scholar
  • 6 Yamauchi T, Kamon J, Waki H. et al. The fatderived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 2001; 07: 941-6.
    CrossrefPubMedGoogle Scholar
  • 7 Berg AH, Combs TP, Du X. et al. The adipocyte-secreted protein Acrp 30 enhances hepatic insulin action. Nature Medicine 2001; 07: 947-53.
    CrossrefPubMedGoogle Scholar
  • 8 Stefan N, Stumvoll M. Adiponectin- its role in metabolism and beyond. Horm Metab Res 2002; 34: 469-74.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Arita Y, Kihara S, Ouchi N. et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79-83.
    CrossrefPubMedGoogle Scholar
  • 10 Matsubara M, Maruoka S, Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol 2002; 147: 173-80.
    CrossrefPubMedGoogle Scholar
  • 11 Weyer C, Funahashi T, Tanaka S. et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86: 1930-5.
    CrossrefPubMedGoogle Scholar
  • 12 Matsubara M, Katayose S, Maruoka S. Decreased plasma adiponectin concentrations in nondiabetic women with elevated homeostasis model assessment ratios. Eur J Endocrinol 2003; 148: 343-50.
    CrossrefPubMedGoogle Scholar
  • 13 Hotta K, Funahashi T, Arita Y. et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000; 20: 1595-9.
    CrossrefPubMedGoogle Scholar
  • 14 Matsubara M, Maruoka S, Katayose S. Decreased plasma adiponectin concentrations in women with dyslipidemia. J Clin Endocrinol Metab 2002; 87: 2764-9.
    CrossrefPubMedGoogle Scholar
  • 15 Matsubara M, Namioka K, Katayose S. Decreased plasma adiponectin concentrations in women with low-grade C-reactive protein elevation. Eur J Endocrinol 2003; 148: 657-62.
    CrossrefPubMedGoogle Scholar
  • 16 Zoccali C, Mallamaci F, Tripepi G. et al. Adiponectin, metabolic risk factors, and cardiovascular events among patients with endstage renal disease. J Am Soc Nephrol 2002; 13: 134-41.
    PubMedGoogle Scholar
  • 17 Kissebah AH, Sonnenberg GE, Myklebust J. et al. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci USA 2000; 97: 14478-83.
    CrossrefPubMedGoogle Scholar
  • 18 Vionnet N, Hani El-H, Dupont S. et al. Genome wide search for type 2 diabetes-susceptibility gene in French white: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Gen 2000; 67: 1470-80.
    CrossrefPubMedGoogle Scholar
  • 19 Takahashi M, Arita Y, Yamagata K. et al. Genomic structure and mutations in adipose-specific gene, adiponectin. Int J Obes 2000; 24: 861-8.
    CrossrefPubMedGoogle Scholar
  • 20 Hara K, Boutin P, Mori Y. et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002; 51: 536-40.
    CrossrefPubMedGoogle Scholar
  • 21 Kondo H, Shimomura I, Matsukawa Y. et al. Association of adiponectin mutation with type 2 diabetes. Diabetes 2002; 51: 2325-8.
    CrossrefPubMedGoogle Scholar
  • 22 Menzaghi C, Ercolino T, Paola RD. et al. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 2002; 51: 2306-2312.
    CrossrefPubMedGoogle Scholar
  • 23 Gimble JM, Robinson CE, Wu X. et al. The function of adipocytes in the bone marrow stroma; an update. Bone 1996; 19: 421-8.
    CrossrefPubMedGoogle Scholar
  • 24 Umemoto Y, Tsuji K, Yang FC. et al. Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells. Blood 1997; 90: 3438-43.
    PubMedGoogle Scholar
  • 25 Mikhail AA, Beck EX, Shafer A. et al. Leptin stimulates fetal and adult erythroid and myeloid development. Blood 1997; 89: 1507-12.
    PubMedGoogle Scholar
  • 26 Engeli S, Feldpausch M, Gorzelniak K. et al. Association between adiponectin and mediators of inflammation in obese women. Diabetes 2003; 52: 942-7.
    CrossrefPubMedGoogle Scholar
  • 27 Fernandez-Real JM, Lopez-Bermejo A, Casamitjana R. et al. Novel interactions of adiponectin with the endocrine system and inflammatory parameters. J Clin Endocrinol Metab 2003; 88: 2714-8.
    CrossrefPubMedGoogle Scholar
  • 28 Mantzoros CS. The role of leptin in human obesity and disease: A review of current evidence. Ann Intern Med 1999; 130: 671-80.
    CrossrefPubMedGoogle Scholar
  • 29 Matsubara M, Yoshizawa T, Morioka T. et al. Serum leptin and lipids in patients with thyroid dysfunction. J Atheroscler Thromb 2000; 07: 50-4.
    CrossrefPubMedGoogle Scholar
  • 30 Maeda N, Shimomura I, Kishida K. et al. Dietinduced insulin resistance in mice lacking adiponectin/ACRP30. Nature Medicine 2002; 08: 731-7.
    CrossrefPubMedGoogle Scholar
  • 31 Kubota N, Terauchi Y, Yamauchi T. et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 2002; 277: 25863-66.
    CrossrefPubMedGoogle Scholar
  • 32 Nakata M, Yada T, Soejima N. et al. Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes 1999; 48: 426-9.
    CrossrefPubMedGoogle Scholar
  • 33 Bodary PF, Westrick RJ, Wickenheiser KJ. et al. Effects of leptin on arterial thrombosis following vascular injury in mice. JAMA 2002; 287: 1706-9.
    CrossrefPubMedGoogle Scholar
  • 34 Hill JM, Zalos G, Halcox JPJ. et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003; 348: 593-600.
    CrossrefPubMedGoogle Scholar
  • 35 Kaplan LM. Leptin, obesity, and liver disease. Gastroenterology 1998; 115: 997-1001.
    CrossrefPubMedGoogle Scholar
  • 36 Henriksen JH, Holst JJ, Moller S. et al. Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal. Hepatology 1999; 29: 1818-24.
    CrossrefPubMedGoogle Scholar
  • 37 Xu A, Wang Y, Keshaw H. et al. The fatderived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003; 112: 91-100.
    CrossrefPubMedGoogle Scholar
  • 38 McCullough AJ, Bugianesi E, Marchesini G. et al. Gender-dependent alterations in serum leptin in alcoholic cirrhosis. Gastroenterology 1998; 115: 947-53.
    CrossrefPubMedGoogle Scholar