Neuropediatrics 2008; 39(2): 134-136
DOI: 10.1055/s-2008-1081459
Short Communication

© Georg Thieme Verlag KG Stuttgart · New York

Severe Form of Acute Influenza Encephalopathy with Biphasic Seizures and Late Reduced Diffusion

H. Tada 1 , 3 , J.-i. Takanashi 1 , H. Terada 2 , K. Tajima 3
  • 1Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan
  • 2Department of Radiology, Toho University Sakura Medical Center, Sakura, Japan
  • 3Department of Pediatrics, Kimitsu Central Hospital, Kisarazu, Japan
Further Information

Publication History

received 17.03.2008

accepted 10.06.2008

Publication Date:
31 July 2008 (online)

Abstract

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is clinically characterized by biphasic seizures on days 1, and 4 to 6; radiologically by no acute abnormality is visible during the first two days, while reduced diffusion in the subcortical white matter is seen during days 3 to 9, finally resulting in cerebral atrophy. We report here a Japanese child with clinically severe AESD associated with influenza A, whose sequential magnetic resonance imaging revealed cerebral swelling on day 1, reduced diffusion and central herniation on day 6, followed by cortical laminar necrosis and atrophy on day 30. The findings from this patient suggests that AESD has clinically and radiologically a wider spectrum than previously considered.

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Correspondence

J.-i. TakanashiMD 

Department of Pediatrics

Kameda Medical Center

929 Higashi-cho

Kamogawa-shi

Chiba 296-8602

Japan

Phone: +81/470/92 22 11

Fax: +81/470/99 11 98

Email: jtaka@kameda.jp