Z Gastroenterol 2008; 46 - A5
DOI: 10.1055/s-2008-1079609

Effect of high resveratrol content red wine versus ethanol on homeostasis in rats

A Blázovics 1, H Fébel 2, E Székely 3, G Bekő 4, E Szőke 5, K Szentmihályi 6, É Sárdi 7
  • 1II. Department of Medicine, Semmelweis University, Budapest
  • 2Research Institute for Animal Breeding and Nutrition, Herceghalom
  • 3Chemical Research Center, Hungarian Academy of Sciences, Budapest
  • 4Central Hospital of the Hungarian State Railways, Budapest
  • 5Central Laboratory (Pest) of Semmelweis University, Budapest
  • 6Department of Oral Biology, Semmelweis University
  • 7Corvinus University of Budapest, Faculty of Horticultural Science, Department of Genetic and Plant Breeding

Introduction: S-adenosyl-methyonine concentration is lowered by ethanol consumption and therefore several metabolic pathways are inhibited. The endogenous transmethylating processes occur via HCHO. Bounded HCHO level and scavenger capacity are in significant correlation, and their roles were justified in proliferative and apoptotic processes. The aims were to study the transmethylating activity during red wine consumption compared to ethanol and anti-inflammatory effect of resveratrol rich (12.03mg/l) red wine. Methods: Rats were treated with red wine (RW) (N=5) (Egri Cuvée/10.5 ethanol/8ml/bwkgxday) and ethanol (ALC) (N=5) (/10.5%/8ml/bwkgxday) for 10 days Control (C) group (N=5) was kept on water. Evidence Biochip Array Analyser was applied to quantify serum levels of interleukins. Laboratory tests were determined with Roche metods by Hitachi Modular. Redox parameters were measured with Jasco V 550 spectrophotometer and Berthold Lumat 9501 luminometer. Results and Discussion: Significant differences were not observed in routine parameters among groups in general. Redox-parameters (SOD, GSHPx, scavenger capacity) were not improved during red wine treatment compared to control and alcohol treated groups, in spite of H-donating ability. It was the highest in the RW group (1.21±1.11mg/ml). IL-2 (pg/ml) level was lowered in ALC animals (1.64±2.8) compared with RW group (2.9±3.3), and IL-4 (pg/ml) was 4.42±1.29 in ALC group and RW group 2.07±1.39. CRP was significantly high in RW group:0.17±0.26mg/dl. Transmethylating ability (HCHO µg/µl) of liver was significantly better in RW group 9.8×10–3±1.4×10–3 compared with C group 6.4×10–3±1.1×10–3 and significantly low in ALC group: 4.2×10–3±1.1×10–3. Results showed that red wine consumption influenced the redox homeostasis, immune reactivities and transmethylating processes, but the applied concentration was not beneficial from all points of view, especially in inflammatory parameters compared with ethanol in the same dose, in spite of the reducing capacity, which increased in the plasma and methylating ability of the liver. ETT 012/2006