Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2008(8): 0834-0834
DOI: 10.1055/s-2008-1078552
DOI: 10.1055/s-2008-1078552
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Kilogram-Scale Asymmetric Rhodium-Catalyzed 1,4-Addition
S. Brock, D. R. J. Hose, J. D. Moseley, A. J. Parker*, I. Patel, A. J. Williams
AstraZeneca, Bristol, UK
Further Information
Publication History
Publication Date:
23 July 2008 (online)
Significance
The authors describe the implementation of an enantioselective rhodium-catalyzed 1,4-conjugate addition of 3,5-difluorophenyl boronic acid to various α,β-unsaturated esters. Remarkably, while previous reports required 2-10 equivalents of boron species due to a rhodium-mediated protodeboronation pathway, the authors found that the use of one equivalent of i-PrOH instead of water significantly suppressed this side reaction.