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Synfacts 2008(10): 1017-1017  
DOI: 10.1055/s-2008-1078286
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of 7-Epi (+)-FR900482

Contributor(s): Philip Kocienski, Indu Dager
B. M. Trost*, B. M. O’Boyle
Stanford University, USA
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

Due to its superior activity against several cancer cell lines and decreased toxicity compared to mitomycin C, FR900482 has been investigated as a replacement candidate for mitomycin C. The synthesis of key intermediate E features a highly stereoselective Pd-catalyzed DYKAT (dynamic catalytic asymmetric transformation) reaction.